INT239538

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (CXCR4, CALCRL) plasma membrane (CXCR4, CALCRL) endosome (CALCRL)
endoplasmic reticulum (CALCRL) cytoplasm (CXCR4) protein transporter activity (CALCRL)
Anatomy Link Frequency
immune cells 1
CXCR4 (Homo sapiens)
CALCRL (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 15 100.00 Very High Very High Very High
agonist 19 97.24 Very High Very High Very High
opiate 1 95.60 Very High Very High Very High
Opioid 5 88.16 High High
opioid receptor 19 76.40 Quite High
Cannabinoid 2 70.28 Quite High
Potency 3 67.84 Quite High
antagonist 13 62.32 Quite High
MU agonist 8 5.00 Very Low Very Low Very Low
Enkephalin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 1 97.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 3 96.64 Very High Very High Very High
Obesity 1 66.92 Quite High
Bordatella Infection 8 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Stomatitis 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, very recent studies by Pello et al. [59] have shown that interactions between the chemokine CXCR4 receptor and the DOP receptor have functional consequences in immune cells in that co-addition of agonist ligands for these receptors fail to generate function, leading to a suppression of signalling potentially because the heterodimer produces a dominant-negative effect.
CXCR4 receptor Binding (interactions) of receptor in immune cells associated with chemokine and agonist
1) Confidence 0.00 Published 2008 Journal Biochemical Journal Section Body Doc Link PMC2474558 Disease Relevance 0.35 Pain Relevance 0.71

General Comments

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