INT239661

Context Info Confidence 0.06 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.16 Pain Relevance 0

nucleoplasm (NR2E3) signal transduction (NR2E3) nucleus (NR2E3)

NR2E3 (Homo sapiens)

Pain Link Frequency Relevance Heat Bile 2 41.04 cytokine 5 5.00 tolerance 4 5.00 fibrosis 2 5.00 withdrawal 2 5.00 ischemia 1 5.00 Inflammation 1 5.00 Pain 1 5.00 alcohol 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Congenital Anomalies 1 97.20 Disease 3 67.28 Liver Disease 10 50.00 Aging 2 29.72 Fever 12 5.00 Cirrhosis 12 5.00 Injury 9 5.00 Stress 5 5.00 Obesity 4 5.00 Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

ESCs can be indefinitely maintained in an undifferentiated state, though they seem to develop karyotypic abnormalities over long periods in culture [5].

Negative_regulation (maintained) of ESCs associated with congenital anomalies

1) Confidence 0.06 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2963137 Disease Relevance 0.16 Pain Relevance 0

Targeted knockdown of SMAD 4 in decidualized ESCs using two independent siRNAs (n?

Negative_regulation (knockdown) of ESCs

2) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945765 Disease Relevance 0 Pain Relevance 0

Of course, one, two or the three RNR might have been present in LUCA (or in its community see below) and differentially lost thereafter, but this is only hypothetical and cannot guaranty us that LUCA had a DNA genome.

Negative_regulation (lost) of RNR

3) Confidence 0.02 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.