INT239662

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SH3D19) Golgi apparatus (SH3D19) nucleolus (SH3D19)
plasma membrane (SH3D19) nucleus (SH3D19) cytoskeleton organization (SH3D19)
Anatomy Link Frequency
internal 1
mere 1
SH3D19 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 36 96.36 Very High Very High Very High
Stress 15 95.74 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Author's response: As already explained in our answer to Dr Poole, we do not wish to trace all phylogenetic incongruencies to loss of paralogues and we do not deny the occurrence of LGT (or HGT) but, as one of us already mentioned in a previous paper (ref 29), we stress that assuming an interdomain LGT (rare as you also emphasize) does not gain much credibility from the mere occurrence of a phylogenetic anomaly but well from the possibility of selection, such as in the case of reverse gyrase.
Gene_expression (gyrase) of eve in mere associated with stress
1) Confidence 0.65 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.16 Pain Relevance 0
For instance, the transfer of reverse gyrase from Archaea to some bacteria has probably helped their adaptation to extremely high temperature whereas the transfer of gyrase from Bacteria to some archaea has profoundly changed the internal topology of their DNA.
Gene_expression (transfer) of eve in internal associated with fever
2) Confidence 0.58 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.10 Pain Relevance 0
It should be clear that we are not rejecting the notion that a certain proportion of phylogenetic incongruencies are due to HGT; even between Domains, the transfer of genes with pleiotropic effects (such as reverse gyrase or other topoisomerases [44,188] appears to have occurred, presumably under selection; this type of event seems however infrequent and contrasts with the indiscriminate recourse to HGT found in many publications.
Gene_expression (transfer) of eve
3) Confidence 0.58 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0

General Comments

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