INT240059

Context Info Confidence 0.48 First Reported 2008 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 3.96 Pain Relevance 1.59

cell differentiation (RHOB) endosome (RHOB) intracellular (RHOB) GTPase activity (RHOB) cytosol (RHOB) cell adhesion (RHOB)

Anatomy Link Frequency knee 4 RHOB (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 198 99.56 Arthritis 24 85.12 Pain 12 5.00 Inflammation 6 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Knee Osteoarthritis 186 99.56 Togavirus Infection 123 99.44 Disease 14 97.76 Arthritis 18 85.12 Death 6 84.44 Apoptosis 6 84.00 Osteoarthritis 12 77.04 Arthropathy 12 58.72 Hepatitis A Virus Infection 2 33.88 Obesity 24 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The association of TXNDC3 with knee OA was replicated in East Asian individuals, whereas a lack of association for RHOB was identified.

RHOB Binding (association) of in knee associated with osteoarthritis

1) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.33 Pain Relevance 0.17

No significant associations were found for RHOB in any other comparisons in the East Asian populations.

RHOB Neg (No) Binding (associations) of

2) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.47 Pain Relevance 0.23

However, a replication study in the UK found no association of RHOB and TXNDC3 with knee OA, even though the ethnicity and disease ascertainment were basically the same in the two studies [10].

RHOB Neg (no) Binding (association) of in knee associated with disease and osteoarthritis

3) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 1.00 Pain Relevance 0.34

Marh and coworkers [7] examined regulatory polymorphisms in the 5' regions of the genes that potentially allow for differential expression in vivo, and they found positive association for RHOB and TXNDC3 in European Caucasians living in Germany.

RHOB Binding (association) of

4) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483443 Disease Relevance 0.95 Pain Relevance 0.40

A significant association of RHOB with knee OA was observed in male Chinese patients (P = 0.02).

RHOB Binding (association) of in knee associated with osteoarthritis

5) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.49 Pain Relevance 0.24

Conflicting findings on the association of single nucleotide polymorphisms (SNPs) in RHOB and TXNDC3 with susceptibility to knee osteoarthritis (OA) have been reported in European Caucasians.

RHOB Binding (association) of in knee associated with knee osteoarthritis and osteoarthritis

6) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2483443 Disease Relevance 0.42 Pain Relevance 0.21

The ELISA binding affinity of the three human IgG antibodies, F5, H6, and G1, for VEEV TC-83 was equivalent to that of mMAb 3B4C-4 (Figure S4).

H6 Binding (affinity) of associated with togavirus infection

7) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.31 Pain Relevance 0

General Comments

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