INT24019

Context Info Confidence 0.37 First Reported 1980 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 7.94 Pain Relevance 1.04

pigmentation (HPS1) cytoplasmic membrane-bounded vesicle (HPS1) lysosome (HPS1) cytoplasm (HPS1)

HPS1 (Homo sapiens)

Pain Link Frequency Relevance Heat lidocaine 7 99.56 cytokine 4 93.36 alcohol 65 74.00 Neurotransmitter 1 71.44 cva 6 61.72 Hippocampus 3 61.52 tetrodotoxin 1 58.56 Opioid 1 51.04 addiction 10 50.48 noradrenaline 1 44.08

Disease Link Frequency Relevance Heat Hantavirus Infection 46 100.00 Diabetes Mellitus 7 98.52 Atherosclerosis 14 97.68 Hypertension 2 96.04 Hemophagocytic Lymphohistiocytosis 52 93.76 Peripheral Arterial Disease 7 93.40 Malignant Neoplastic Disease 8 92.96 Viral Infection 2 92.00 Cerebrovascular Disease 1 91.72 Coronary Artery Disease 29 90.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Most studies of HPs in treatment suggest an age for substance related impairment to be middle adulthood and HPs younger than 35 tend to abuse a combination of AOD [33].

Negative_regulation (impairment) of HPs

1) Confidence 0.37 Published 2008 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2265282 Disease Relevance 0.11 Pain Relevance 0.23

There was a marked decrease in input resistance during the HPs.

Negative_regulation (decrease) of HPs

2) Confidence 0.37 Published 1987 Journal Brain Res. Section Abstract Doc Link 2441803 Disease Relevance 0 Pain Relevance 0.13

Thus, lidocaine causes a significant decrease in retrograde refractoriness within the HPS in patients with normal intraventricular conduction.

Negative_regulation (decrease) of HPS associated with lidocaine and hantavirus infection

3) Confidence 0.35 Published 1980 Journal Circulation Section Abstract Doc Link 7397979 Disease Relevance 0.75 Pain Relevance 0.56

However, these guidelines are not satisfactory in diagnosing HPS in adults; therefore, a number of studies on adult HPS have used their own criteria [1,3,4].

Negative_regulation (number) of HPS associated with hantavirus infection

4) Confidence 0.12 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC527873 Disease Relevance 2.19 Pain Relevance 0

It seems likely that hypercytokinemia due to surgical resection might have contribute to the development of HPS in the present case.

Negative_regulation (development) of HPS associated with hantavirus infection

5) Confidence 0.12 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC527873 Disease Relevance 1.71 Pain Relevance 0.09

9%), this coupled with higher cost reduction in HPS (22% reduction in hospital costs compared with 13%) means that the HPS ICER of £4500 is approximately consistent with our ICER of £1840.

Negative_regulation (reduction) of HPS associated with hantavirus infection

6) Confidence 0.09 Published 2010 Journal European Journal of Heart Failure Section Body Doc Link PMC2796144 Disease Relevance 0.85 Pain Relevance 0

Compared with placebo, simvastatin decreased serum LDL cholesterol by 39% (HPS 2002).

Negative_regulation (decreased) of HPS associated with hantavirus infection

7) Confidence 0.03 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2699649 Disease Relevance 2.33 Pain Relevance 0.03

General Comments

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