INT24041

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 8.39
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SNRPA1) RNA binding (SNRPA1) nucleus (SNRPA1)
Anatomy Link Frequency
surface epithelium 2
pancreas 1
Acinar cells 1
SNRPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 162 100.00 Very High Very High Very High
Chronic pancreatitis 6 97.52 Very High Very High Very High
peptic ulcer disease 13 23.04 Low Low
Inflammatory response 20 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 172 100.00 Very High Very High Very High
Gastritis 157 99.12 Very High Very High Very High
Malignant Neoplastic Disease 5 98.86 Very High Very High Very High
Infection 385 98.84 Very High Very High Very High
Pancreatitis 6 97.52 Very High Very High Very High
Pancreatic Cancer 6 96.48 Very High Very High Very High
Gastrointestinal Neoplasms 2 93.24 High High
Sprains And Strains 225 91.12 High High
Cancer 19 79.04 Quite High
Metaplasia 7 75.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, malignant transformation has been reported to confer a pronounced expression of Lea, sLea, and sdiLex in the gastric mucosa [19,53].
Gene_expression (expression) of Lea associated with malignant neoplastic disease
1) Confidence 0.75 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.74 Pain Relevance 0.08
Furthermore, malignant transformation has been reported to confer a pronounced expression of Lea, sLea, and sdiLex in the gastric mucosa [19,53].
Gene_expression (expression) of Lea associated with malignant neoplastic disease
2) Confidence 0.75 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.74 Pain Relevance 0.08
Importantly, sLea and sLex expression in surface epithelium of antrum correlated with both H. pylori density and gastritis scores (see Table 1B).


Gene_expression (expression) of Lea in surface epithelium associated with gastritis
3) Confidence 0.75 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.59 Pain Relevance 0
H. pylori infection and gastritis have been found to enhance gastric mucosal expression of the inflammation associated sLex/sLea antigens [15].
Gene_expression (expression) of Lea associated with inflammation, gastritis and infection
4) Confidence 0.58 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.76 Pain Relevance 0.08
Acinar cells expressed A, B, H, and Leb in supranuclear cytoplasm, whereas Lea was found mainly on centroacinar cells.
Gene_expression (found) of Lea in Acinar cells
5) Confidence 0.31 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 0.80 Pain Relevance 0.25
The present immunohistochemical study analyzed simultaneously the expression of A, B, H, Lewisa (Lea), and Lewisb (Leb) antigens in specimens of normal pancreas, chronic pancreatitis, and pancreatic carcinoma (primary and metastatic).
Spec (analyzed) Gene_expression (expression) of Lea in pancreas associated with pancreatic cancer and chronic pancreatitis
6) Confidence 0.31 Published 1987 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 2442445 Disease Relevance 0.63 Pain Relevance 0.16
In all seven Sew monkeys, both Leb and Lea antigens were expressed in surface epithelium before experimental infection (Figure 3A).
Gene_expression (expressed) of Lea in surface epithelium associated with infection
7) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 1.11 Pain Relevance 0
A third and most recently described human secretor phenotype, the weak-secretor phenotype, Sew, is characterized by expression of both Lea and Leb antigens.
Gene_expression (expression) of Lea
8) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0 Pain Relevance 0
However, by 2–4 months, expression of Leb/Lea returned to pre-inoculation levels or higher (Figure 3C).
Gene_expression (expression) of Lea
9) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.97 Pain Relevance 0
In addition, 34/41 (83%) animals expressed both Lea and Leb, an antigen combination that, in humans, is regarded as the characteristics of the weak-secretor phenotype (Sew).
Gene_expression (expressed) of Lea
10) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.51 Pain Relevance 0.03
Only seven monkeys did not express mucosal Lea and they were identified as regular Se.
Neg (not) Gene_expression (express) of Lea
11) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 0.54 Pain Relevance 0.03
At 1–4 weeks after inoculation, Leb (Figure 3B) and/or Lea expression (data not shown) transiently decreased in 5/7 monkeys.
Gene_expression (expression) of Lea
12) Confidence 0.01 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2174967 Disease Relevance 1.00 Pain Relevance 0

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