INT240524

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.62
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Stat4) signal transduction (Stat4) nucleus (Stat4)
DNA binding (Stat4) cytoplasm (Stat4) signal transducer activity (Stat4)
Stat4 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 24 97.96 Very High Very High Very High
Inflammation 158 88.08 High High
agonist 44 86.52 High High
Central nervous system 47 81.60 Quite High
Crohn's disease 21 70.40 Quite High
cytokine 92 68.56 Quite High
rheumatoid arthritis 12 63.84 Quite High
chemokine 16 62.32 Quite High
Arthritis 45 40.64 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 36 98.12 Very High Very High Very High
Demyelinating Disease 30 97.96 Very High Very High Very High
Autoimmune Disease 4 97.96 Very High Very High Very High
INFLAMMATION 167 88.08 High High
Targeted Disruption 9 86.08 High High
Stroke 13 83.36 Quite High
Disease 101 79.92 Quite High
Inflammatory Bowel Disease 24 72.56 Quite High
Rheumatoid Arthritis 18 63.84 Quite High
Diabetes Mellitus 7 44.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the Th1-polarizing signals, IL-12/STAT4, but not IFN-?
Gene_expression (/) of STAT4
1) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.05 Pain Relevance 0.03
STAT4 is required only in the original stimulation, to imprint the gene for reexpression.
Gene_expression (reexpression) of STAT4
2) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Expression of twist1 in Th cells is induced by IL-12/STAT4, NF-?
Gene_expression (/) of STAT4
3) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.69 Pain Relevance 0.27
factors such as Stat4 and T-bet are involved in the pathogenesis of EAE/MS, whereas
Gene_expression (factors) of Stat4 associated with multiple sclerosis
4) Confidence 0.40 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490815 Disease Relevance 0.88 Pain Relevance 0.34

General Comments

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