INT240713

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp2b2) cell morphogenesis (Atp2b2) endoplasmic reticulum (Atp2b2)
plasma membrane (Atp2b2) locomotion (Atp2b2) cilium (Atp2b2)
Anatomy Link Frequency
reticulum 1
Atp2b2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 32 64.96 Quite High
ASIC 4 63.52 Quite High
qutenza 16 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 10 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
tissue acidosis 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 292 99.28 Very High Very High Very High
Cv Unclassified Under Development 28 64.96 Quite High
Nociception 4 53.64 Quite High
Increased Venous Pressure Under Development 4 20.80 Low Low
Acidosis 6 5.00 Very Low Very Low Very Low
Alkalosis 4 5.00 Very Low Very Low Very Low
Coronary Artery Disease 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relative contributions of SERCA versus PMCA to Ca2+ clearance must therefore depend on the conditions in which such measurements are made.
Gene_expression (clearance) of PMCA
1) Confidence 0.14 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.40 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Gene_expression (extrusion) of PMCA in reticulum associated with hypoxia
2) Confidence 0.14 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0.09

General Comments

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