INT240849

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.74
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Irs1) signal transduction (Irs1) plasma membrane (Irs1)
nucleus (Irs1) cytoplasm (Irs1) signal transducer activity (Irs1)
Anatomy Link Frequency
fat 2
liver 2
Irs1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 107 100.00 Very High Very High Very High
Inflammation 119 90.96 High High
Bioavailability 2 81.08 Quite High
Kinase C 30 77.20 Quite High
tolerance 53 41.20 Quite Low
chemokine 14 26.32 Quite Low
fibrosis 33 6.20 Low Low
agonist 33 5.00 Very Low Very Low Very Low
Bile 17 5.00 Very Low Very Low Very Low
alcohol 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 15 100.00 Very High Very High Very High
Insulin Resistance 210 95.08 Very High Very High Very High
Diabetes Mellitus 148 92.12 High High
Obesity 263 91.20 High High
INFLAMMATION 132 90.96 High High
Stress 58 89.76 High High
Increased Venous Pressure Under Development 23 89.56 High High
Apoptosis 24 86.76 High High
Atherosclerosis 2 82.28 Quite High
Hyperinsulinism 15 78.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, serine phosphorylation has been shown to interfere with the tyrosine phosphorylation of IRS-1 (32).
Negative_regulation (interfere) of Phosphorylation (phosphorylation) of IRS-1
1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.32 Pain Relevance 0.04
As illustrated (Fig. 5), the first pathway involves reduction of the tyrosine phosphorylation of IRS-1/2.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of IRS-1
2) Confidence 0.26 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.85 Pain Relevance 0.24
These findings indicate that the increase of insulin-stimulated tyrosine phosphorylation of IRS-1 by the reduction of ROS in liver of db/db mice is associated with the decreased phosphorylation of IRS-1 at the Ser307 residue.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of IRS-1 in liver
3) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.07 Pain Relevance 0.04
With regard to the changes in expression and tyrosine phosphorylation of IRS-1, reduction of ROS attenuated phosphorylation of IRS-1 at the Ser307 residue.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of IRS-1
4) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.15 Pain Relevance 0
IRS-1 is phosphorylated at Ser307 residue (5,19,20) by several cytokines; this modification reduces insulin-stimulated tyrosine phosphorylation of IRS-1 and stimulates the degradation of IRS-1 (21,22).
Negative_regulation (reduces) of Phosphorylation (phosphorylation) of IRS-1 associated with cytokine
5) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0 Pain Relevance 0.05
As shown in Fig. 4B, phosphorylation of IRS-1 at the Ser307 residue was reduced by reduction of ROS.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of IRS-1
6) Confidence 0.21 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.05 Pain Relevance 0.04
Consequently, the reduced tyrosine phosphorylation of IRS-1 and IRS-2 in rat hepatoma cells exposed to palmitic acid can be reversed by inhibition of acyl-CoA synthesis of palmitoyl-CoA, suggesting an important role of FATP (ACSLV) proteins in insulin signaling [50].
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of IRS-1 associated with hepatocellular cancer
7) Confidence 0.13 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.90 Pain Relevance 0
JNK adenovirus overexpression increases serine phosphorylation of IRS-1 with decreased IRS-1 tyrosine phosphorylation and increased SREBP-1c activation, resulting in increased fat synthesis and storage.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of IRS-1 in fat
8) Confidence 0.13 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.72 Pain Relevance 0.07
Consequently, the reduced tyrosine phosphorylation of IRS-1 and IRS-2 in rat hepatoma cells exposed to palmitic acid can be reversed by inhibition of acyl-CoA synthesis of palmitoyl-CoA, suggesting an important role of FATP (ACSLV) proteins in insulin signaling [50].
Negative_regulation (reversed) of Phosphorylation (phosphorylation) of IRS-1 associated with hepatocellular cancer
9) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2840373 Disease Relevance 0.97 Pain Relevance 0
As expected, U0126 inhibited cytokine-induced IRS-1 serine phosphorylation (Fig. 3D and E).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of IRS-1 associated with cytokine
10) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.29 Pain Relevance 0.23
and is implicated in IRS-1 serine phosphorylation.
Negative_regulation (implicated) of Phosphorylation (phosphorylation) of IRS-1
11) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797946 Disease Relevance 0.42 Pain Relevance 0.14

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