INT241040

Context Info Confidence 0.15 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.35 Pain Relevance 0.09

response to stress (Slc8a1, Ca2) cytosol (Ca2) extracellular space (Ca2) mitochondrion (Slc8a1) lyase activity (Ca2) plasma membrane (Slc8a1)

Slc8a1 (Rattus norvegicus) Ca2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat action potential duration 12 94.16 Action potential 18 5.00 anesthesia 2 5.00 halothane 2 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 152 92.28 Stress 36 86.72 Diabetic Cardiomyopathies 26 5.00 Disorder Of Lipid Metabolism 8 5.00 Muscle Disease 6 5.00 Coronary Heart Disease 4 5.00 Body Weight 4 5.00 Arrhythmia Under Development 2 5.00 Coronary Artery Disease 2 5.00 Syndrome 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is well known that maintained depolarization slows the return of [Ca2+]i to resting levels (37), an effect that is partly due to inhibition of Ca2+ extrusion by NCX.

NCX Negative_regulation (inhibition) of Gene_expression (extrusion) of Ca2

1) Confidence 0.15 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.68 Pain Relevance 0.05

It is well known that maintained depolarization slows the return of [Ca2+]i to resting levels (37), an effect that is partly due to inhibition of Ca2+ extrusion by NCX.

NCX Negative_regulation (inhibition) of Gene_expression (extrusion) of Ca2

2) Confidence 0.15 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

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