INT241072

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.36

signal transduction (Oprm1) nuclear envelope (Tpr) plasma membrane (Oprm1) molecular_function (Tpr) signal transducer activity (Oprm1)

Anatomy Link Frequency neuronal 2 Tpr (Mus musculus) Oprm1 (Mus musculus)

Pain Link Frequency Relevance Heat opioid receptor 11 99.54 Morphine 3 93.08 Opioid 3 75.00 addiction 2 5.00 tolerance 2 5.00 dopamine receptor 1 5.00 Central nervous system 1 5.00 Analgesic 1 5.00 analgesia 1 5.00 potassium channel 1 5.00

Disease Link Frequency Relevance Heat Neuroblastoma 4 83.76 Hypersensitivity 3 5.00 Cancer 1 5.00 Apoptosis 1 5.00 Targeted Disruption 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

opioid receptor gene (Oprm1) proximal promoter was found to be important for regulating Oprm1 in neuronal cells.

promoter Positive_regulation (important) of Regulation (regulating) of Oprm1 in neuronal associated with opioid receptor

1) Confidence 0.01 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2494908 Disease Relevance 0.08 Pain Relevance 0.36

General Comments

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