INT241118

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.01
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vhl) mitochondrion (Vhl) nucleus (Vhl)
extracellular matrix organization (Vhl) transcription factor binding (Vhl) cytoplasm (Vhl)
Anatomy Link Frequency
kidney 1
Vhl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 1 95.64 Very High Very High Very High
Central nervous system 6 67.40 Quite High
palliative 3 44.64 Quite Low
imagery 1 32.20 Quite Low
cytokine 7 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 5 100.00 Very High Very High Very High
Renal Cancer 180 99.88 Very High Very High Very High
Syndrome 74 98.46 Very High Very High Very High
Disease 40 94.96 High High
Metastasis 124 88.44 High High
Hypoxia 4 85.68 High High
Toxicity 11 82.52 Quite High
Death 7 75.56 Quite High
Pancreatic Cyst 1 71.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RCC, the loss of function of the Von Hippel Lindau (VHL) tumor supressor gene mediates up-regulation of CXCR4 [29] which then promotes tumor spread and progression [28].
Negative_regulation (loss) of VHL associated with cancer, von hippel-lindau syndrome and renal cancer
1) Confidence 0.11 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2942853 Disease Relevance 1.61 Pain Relevance 0.05
In VHL, patients inherit a
Negative_regulation (inherit) of VHL
2) Confidence 0.06 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2495021 Disease Relevance 1.16 Pain Relevance 0.03
The most common type of RCC is clear cell (ccRCC), about 75% of kidney cancers.15 Families with the rare von Hippel Lindau syndrome develop vascular tumors including ccRCC, and studies indentified underlying loss of a recessive tumor suppressor gene now known as the VHL gene.
Negative_regulation (loss) of VHL in kidney associated with cancer, syndrome and renal cancer
3) Confidence 0.04 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880340 Disease Relevance 1.24 Pain Relevance 0

General Comments

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