INT241538

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Abl1, Lyn) nucleus (Abl1, Lyn) kinase activity (Abl1, Lyn)
mitochondrion (Abl1) Golgi apparatus (Lyn) enzyme binding (Lyn)
Abl1 (Mus musculus)
Lyn (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 4 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
beta blocker 1 5.00 Very Low Very Low Very Low
carbamazepine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 9 85.12 High High
Leukemia 14 56.16 Quite High
Myeloid Leukemia 86 45.92 Quite Low
Apoptosis 2 34.48 Quite Low
Toxicity 13 18.40 Low Low
Pressure And Volume Under Development 23 5.00 Very Low Very Low Very Low
Blast Crisis 19 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Heart Rate Under Development 9 5.00 Very Low Very Low Very Low
Hepatotoxicity 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides Abl, ON012380 showed inhibitory activity against PDGFR kinases and the Src family member Lyn.


Negative_regulation (inhibitory) of Abl Binding (activity) of Lyn
1) Confidence 0.11 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503652 Disease Relevance 0.14 Pain Relevance 0

General Comments

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