INT24160

Context Info Confidence 0.65 First Reported 1983 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 7 Total Number 7 Disease Relevance 1.42 Pain Relevance 3.46

signal transduction (TRIM13) endoplasmic reticulum (TRIM13) intracellular (TRIM13) ligase activity (TRIM13) cytoplasm (TRIM13) signal transducer activity (TRIM13)

Anatomy Link Frequency NG108-15 1 neurons 1 TRIM13 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 32 100.00 Neuropeptide 8 99.56 Dynorphin 4 99.36 Kinase C 18 98.32 Somatostatin 2 97.56 Glutamate 4 95.84 substance P 1 92.08 chemokine 2 88.08 narcan 2 83.80 opiate 2 79.24

Disease Link Frequency Relevance Heat Cancer 128 99.88 Breast Cancer 12 95.60 Paraganglioma 5 92.60 Metastasis 19 90.08 Adenocarcinoma 2 83.56 Malignant Neoplastic Disease 5 75.00 Solid Tumor 3 60.56 Benign Tumor 1 42.32 Glioma 1 33.56 Neuroblastoma 1 33.20

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Key:

Protein

Mutation

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Anatomy

Negation

Speculation

Pain term

Disease term

Most tumors were positive for [Leu5]-enkephalin (76 per cent), [Met5]-enkephalin (75 per cent), somatostatin (67 per cent), and pancreatic polypeptide (51 per cent), followed by vasoactive intestinal polypeptide (VIP) (43 per cent), substance P (31 per cent), ACTH (28 per cent), calcitonin (23 per cent), bombesin (15 per cent), and neurotensin (12 per cent).

Gene_expression (positive) of Leu5 associated with cancer, somatostatin, enkephalin and substance p

1) Confidence 0.65 Published 1988 Journal Hum. Pathol. Section Abstract Doc Link 2447010 Disease Relevance 0.58 Pain Relevance 0.44

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1-17) on neocortical neurons in vitro.

Gene_expression (Actions) of Leu5 in neurons associated with dynorphin and enkephalin

2) Confidence 0.65 Published 1984 Journal Neuropeptides Section Title Doc Link 6152323 Disease Relevance 0 Pain Relevance 0.74

Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in membrane potential or membrane input resistance.

Gene_expression (Application) of Leu5 associated with glutamate and enkephalin

3) Confidence 0.65 Published 1984 Journal Neuropeptides Section Abstract Doc Link 6152323 Disease Relevance 0 Pain Relevance 0.70

The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins.

Gene_expression (synthesis) of Leu5 associated with enkephalin

4) Confidence 0.65 Published 1983 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 6615520 Disease Relevance 0 Pain Relevance 0.29

The neuropeptide leucine-enkephalin ([Leu5]-enkephalin) has been covalently labelled with the two organometallic Mo carbonyl complexes Mo(R-His)(allyl)(CO)2 (His = N delta,N,O-L-histidinate) and Mo(R-bpa)(CO)3 (bpa = bis(2-picolyl)a-mine) on the resin as the last step of a solid-phase synthesis scheme and in solution.

Gene_expression (labelled) of Leu5 associated with neuropeptide and enkephalin

5) Confidence 0.65 Published 2002 Journal Chem. Commun. (Camb.) Section Abstract Doc Link 12125577 Disease Relevance 0 Pain Relevance 0.32

The presence of both Met5- and Leu5-enkephalin-like activities in NG108-15 cells was confirmed in acid extracts of cells by radioreceptor assay after separation by reverse phase high pressure liquid chromatography.

Gene_expression (presence) of Leu5 in NG108-15 associated with enkephalin

6) Confidence 0.58 Published 1983 Journal J. Neurosci. Section Abstract Doc Link 6193253 Disease Relevance 0 Pain Relevance 0.58

to a monomeric red fluorescent protein (mRFP1) and introduced this fusion protein into the mammary cells already stably expressing CXCR4-GFP.

Gene_expression (introduced) of mRFP1

7) Confidence 0.01 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.83 Pain Relevance 0.38

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