INT241687

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.26
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
pancreatic ducts 2
optic disc 1
Cdkn2a (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 2 94.32 High High
Immobilon 1 93.60 High High
Inflammation 4 93.04 High High
cytokine 1 86.60 High High
Chronic pancreatitis 15 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
backache 3 5.00 Very Low Very Low Very Low
wide dynamic range 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 117 99.92 Very High Very High Very High
Diabetes Mellitus 1 99.28 Very High Very High Very High
Disease 37 98.28 Very High Very High Very High
Myocardial Infarction 2 98.12 Very High Very High Very High
Cataract 2 95.20 Very High Very High Very High
Cancer 333 94.64 High High
Fibrosis 5 94.32 High High
Autoimmune Disease 1 93.92 High High
INFLAMMATION 4 93.04 High High
Metastasis 12 81.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membranes were sequentially blocked in 5% dry milk for 1 hour at RT and then incubated with anti-p53, P21 and P16 antibodies at 1?
P16 Binding (antibodies) of
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.10 Pain Relevance 0.05
The CDKN2B/CDKN2A and CDC7/TGFBR3 loci influence the VCDR independently of optic disc area as these genes were not significantly associated with the optic disc area (p>0.05).
CDKN2A Binding (associated) of in optic disc
2) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 1.15 Pain Relevance 0.14
Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12].
Arf-p53 Binding (association) of in pancreatic ducts associated with adenocarcinoma
3) Confidence 0.24 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.32 Pain Relevance 0
Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12].
Ink4a Binding (association) of in pancreatic ducts associated with adenocarcinoma
4) Confidence 0.24 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.32 Pain Relevance 0
The recent generation of mice harboring these signature genetic mutations has yielded models that closely recapitulate the histopathogenesis of the human disease with KrasG12D initiating focal PanINs that rapidly undergo multistage progression in conjunction with Ink4a/Arf or p53 mutations, resulting in invasive PDAC.
Ink4a Binding (conjunction) of associated with adenocarcinoma and disease
5) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.37 Pain Relevance 0

General Comments

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