INT241687
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Membranes were sequentially blocked in 5% dry milk for 1 hour at RT and then incubated with anti-p53, P21 and P16 antibodies at 1? | |||||||||||||||
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The CDKN2B/CDKN2A and CDC7/TGFBR3 loci influence the VCDR independently of optic disc area as these genes were not significantly associated with the optic disc area (p>0.05). | |||||||||||||||
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Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12]. | |||||||||||||||
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Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12]. | |||||||||||||||
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The recent generation of mice harboring these signature genetic mutations has yielded models that closely recapitulate the histopathogenesis of the human disease with KrasG12D initiating focal PanINs that rapidly undergo multistage progression in conjunction with Ink4a/Arf or p53 mutations, resulting in invasive PDAC. | |||||||||||||||
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General Comments
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