INT241687

Context Info Confidence 0.31 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 5.26 Pain Relevance 0.18

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a) protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)

Anatomy Link Frequency pancreatic ducts 2 optic disc 1 Cdkn2a (Mus musculus)

Pain Link Frequency Relevance Heat fibrosis 2 94.32 Immobilon 1 93.60 Inflammation 4 93.04 cytokine 1 86.60 Chronic pancreatitis 15 5.00 metalloproteinase 4 5.00 imagery 4 5.00 Pain 3 5.00 backache 3 5.00 wide dynamic range 3 5.00

Disease Link Frequency Relevance Heat Adenocarcinoma 117 99.92 Diabetes Mellitus 1 99.28 Disease 37 98.28 Myocardial Infarction 2 98.12 Cataract 2 95.20 Cancer 333 94.64 Fibrosis 5 94.32 Autoimmune Disease 1 93.92 INFLAMMATION 4 93.04 Metastasis 12 81.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Membranes were sequentially blocked in 5% dry milk for 1 hour at RT and then incubated with anti-p53, P21 and P16 antibodies at 1?

P16 Binding (antibodies) of

1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.10 Pain Relevance 0.05

The CDKN2B/CDKN2A and CDC7/TGFBR3 loci influence the VCDR independently of optic disc area as these genes were not significantly associated with the optic disc area (p>0.05).

CDKN2A Binding (associated) of in optic disc

2) Confidence 0.28 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2883590 Disease Relevance 1.15 Pain Relevance 0.14

Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12].

Arf-p53 Binding (association) of in pancreatic ducts associated with adenocarcinoma

3) Confidence 0.24 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.32 Pain Relevance 0

Kras activation is thought to initiate focal lesions in the pancreatic ducts, known as pancreatic intraepithelial neoplasias (PanINs), which undergo graded histological progression to PDAC in association with subsequent Ink4a and Arf-p53 inactivation [11,12].

Ink4a Binding (association) of in pancreatic ducts associated with adenocarcinoma

4) Confidence 0.24 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.32 Pain Relevance 0

The recent generation of mice harboring these signature genetic mutations has yielded models that closely recapitulate the histopathogenesis of the human disease with KrasG12D initiating focal PanINs that rapidly undergo multistage progression in conjunction with Ink4a/Arf or p53 mutations, resulting in invasive PDAC.

Ink4a Binding (conjunction) of associated with adenocarcinoma and disease

5) Confidence 0.18 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 1.37 Pain Relevance 0

General Comments

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