INT241853

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.35
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (SLC40A1, HAMP) extracellular region (HAMP) plasma membrane (SLC40A1)
transmembrane transport (SLC40A1)
Anatomy Link Frequency
bone marrow 2
macrophages 1
SLC40A1 (Homo sapiens)
HAMP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 96.84 Very High Very High Very High
Inflammation 15 96.44 Very High Very High Very High
tolerance 2 50.72 Quite High
palliative 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
peptic ulcer disease 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
visual analogue scale 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Disease 10 99.90 Very High Very High Very High
Anaemia 268 99.06 Very High Very High Very High
INFLAMMATION 15 96.44 Very High Very High Very High
Hypoxia 7 95.60 Very High Very High Very High
Chronic Renal Failure 45 89.92 High High
Nutritional Deficiencies 2 87.28 High High
Renal Disease 20 84.88 Quite High
Cancer 141 81.68 Quite High
Renal Insufficiency 3 64.08 Quite High
Disorders Of Creatine Metabolism 3 58.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently published data suggests that hepcidin binds to ferroportin (FPN1), a cellular iron exporter, resulting in internalisation and loss of function [19].
ferroportin Binding (binds) of hepcidin
1) Confidence 0.41 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.94 Pain Relevance 0.13
In macrophages, the binding of hepcidin to FPN1 and its subsequent internalisation would result in iron accumulation within the cell and less release of iron.
FPN1 Binding (binding) of hepcidin in macrophages
2) Confidence 0.41 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.70 Pain Relevance 0.13
Recently published data suggests that hepcidin binds to ferroportin (FPN1), a cellular iron exporter, resulting in internalisation and loss of function [19].
FPN1 Binding (binds) of hepcidin
3) Confidence 0.32 Published 2008 Journal BMC Nephrol Section Body Doc Link PMC2519060 Disease Relevance 0.94 Pain Relevance 0.13
Under other conditions, like in B12 deficiency anemia treatment, this is no problem, but in ACD the hepcidin–ferroportin interaction reduces the possibility for iron provision to the bone marrow.


ferroportin Binding (interaction) of hepcidin in bone marrow associated with anaemia and chronic disease
4) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.39 Pain Relevance 0.03
Under other conditions, like in B12 deficiency anemia treatment, this is no problem, but in ACD the hepcidin–ferroportin interaction reduces the possibility for iron provision to the bone marrow.


ferroportin Binding (interaction) of hepcidin in bone marrow associated with anaemia and chronic disease
5) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.39 Pain Relevance 0.03

General Comments

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