INT241858

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 5.27
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EPCAM)
Anatomy Link Frequency
Ankle 1
EPCAM (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 99.92 Very High Very High Very High
Pain 92 99.24 Very High Very High Very High
Neuropeptide 4 99.20 Very High Very High Very High
cytokine 8 92.52 High High
Analgesic 52 90.12 High High
anesthesia 4 75.44 Quite High
Opioid 8 22.64 Low Low
narcan 20 5.00 Very Low Very Low Very Low
Hyperalgesia 16 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 78 99.92 Very High Very High Very High
Pain 92 99.24 Very High Very High Very High
Sprains And Strains 156 99.00 Very High Very High Very High
Lymphatic System Cancer 46 98.58 Very High Very High Very High
Anaemia 208 97.04 Very High Very High Very High
Cancer 132 96.44 Very High Very High Very High
Pressure And Volume Under Development 116 93.76 High High
Iron Overload 4 72.92 Quite High
Disease Progression 2 69.88 Quite High
Cognitive Disorder 6 68.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ESA with low and high frequencies has been shown to release different neuropepides, suggesting its various therapeutic effects.
Localization (release) of ESA
1) Confidence 0.47 Published 2007 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2693606 Disease Relevance 1.00 Pain Relevance 0.37
Rats were allocated randomly into three groups (2 Hz ESA, 100 Hz ESA or control groups: n=9/group).
Localization (allocated) of ESA
2) Confidence 0.47 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.69 Pain Relevance 0.43
Rats were allocated randomly into three groups (2 Hz ESA, 100 Hz ESA or control groups: n=9/group).
Localization (allocated) of ESA
3) Confidence 0.47 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693606 Disease Relevance 0.69 Pain Relevance 0.43
The Effect of 2 Hz and 100 Hz Electrical Stimulation of Acupoint on Ankle Sprain in Rats

The electrical stimulation of acupoint (ESA) releases several endogenous neuropeptides, which play important roles in management of pain and inflammation.

Localization (releases) of ESA in Ankle associated with pain, inflammation, neuropeptide and sprains and strains
4) Confidence 0.44 Published 2007 Journal Journal of Korean Medical Science Section Title Doc Link PMC2693606 Disease Relevance 1.11 Pain Relevance 0.43
Still, the guidelines state that there was grade B evidence to support improved response of ESA with addition of IV iron and that oral iron is ineffective in functional iron deficiency.


Localization (response) of ESA associated with anaemia
5) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 1.08 Pain Relevance 0.09
In a study of 349 myeloma and lymphoma patients, Österborg and colleagues (2002) confirmed a QoL gain in the ESA-treated patients and a correlation between Hb increase and QoL improvement.


Localization (increase) of ESA associated with lymphatic system cancer
6) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.69 Pain Relevance 0

General Comments

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