INT24191

From wiki-pain
Revision as of 03:53, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1982
Last Reported 2007
Negated 3
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 2.16
Pain Relevance 6.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (VIP)
Anatomy Link Frequency
nerve 3
Merkel cells 1
smooth muscle 1
brains 1
lactotroph 1
VIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
Somatostatin 9 100.00 Very High Very High Very High
Calcitonin gene-related peptide 7 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
bradykinin 1 100.00 Very High Very High Very High
substance P 8 99.80 Very High Very High Very High
Neuropeptide 16 99.48 Very High Very High Very High
narcan 21 97.38 Very High Very High Very High
Cluster headache 2 95.68 Very High Very High Very High
Serotonin 32 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 5 100.00 Very High Very High Very High
Amyloid Plaque 1 98.72 Very High Very High Very High
Disease 6 96.16 Very High Very High Very High
Aggression 2 93.36 High High
Paroxysmal Hemicrania 5 90.72 High High
Headache 2 88.96 High High
Disorders Of The Lacrimal System 1 86.20 High High
Catalepsy 1 86.08 High High
Convulsion 2 83.44 Quite High
Pain 3 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vasoactive intestinal peptide (VIP) relaxes smooth muscle by interacting with receptors coupled to cAMP- or cGMP-signalling pathways.
Vasoactive intestinal peptide Binding (interacting) of in smooth muscle
1) Confidence 0.40 Published 2006 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 17040412 Disease Relevance 0 Pain Relevance 0.08
To test whether VIP might be the endogenous mediator of this effect, nerve stimulation was carried out in the presence of large amounts of exogenous VIP in order to occupy all VIP receptors; the motor inhibitory action of VIP was counteracted by vasopressin.
VIP Binding (occupy) of in nerve
2) Confidence 0.37 Published 1982 Journal Regul. Pept. Section Abstract Doc Link 7063753 Disease Relevance 0 Pain Relevance 0.12
Furthermore, substance P (SP)- and vasoactive intestinal polypeptide (VIP)-IR nerve fibers were closely associated with some Enk-IR cells.
VIP Binding (associated) of in nerve associated with enkephalin and substance p
3) Confidence 0.36 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2448631 Disease Relevance 0 Pain Relevance 0.98
The list of peptides includes, but is not limited to: ACTH, angiotensin, bombesin, bradykinin, calcitonin, casomorphin, CCK, ceruletide, CGRP, CRF, dermorphin, DSIP, dynorphin, endorphins, enkephalins, GRF, gastrin, LHRH, litorin, metkephamid, MIF-l, motilin, MSH, NPY, NT, oxytocin, ranatensin, sauvagine, substances P and K, somatostatin, TRH, VIP, vasopressin, and vasotocin.
VIP Binding (limited) of associated with dynorphin, somatostatin, enkephalin and bradykinin
4) Confidence 0.36 Published 1986 Journal Peptides Section Abstract Doc Link 3534808 Disease Relevance 0.34 Pain Relevance 0.54
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
vasoactive intestinal peptide Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
5) Confidence 0.36 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.59
Moreover, successful treatment of the problem with indomethacin leads to normalization of the levels of both CGRP and VIP.
VIP Binding (normalization) of associated with calcitonin gene-related peptide
6) Confidence 0.36 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8902256 Disease Relevance 0.81 Pain Relevance 1.22
SO demonstrated immunoreactivity for VIP, PHI (PHM), neuropeptide Y, CGRP, galanin, somatostatin, substance P, and enkephalin, but no immunoreactivity was observed for bombesin.
VIP Binding (immunoreactivity) of associated with somatostatin, neuropeptide, enkephalin, substance p and calcitonin gene-related peptide
7) Confidence 0.32 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8313811 Disease Relevance 0.50 Pain Relevance 0.74
To test whether VIP might be the endogenous mediator of this effect, nerve stimulation was carried out in the presence of large amounts of exogenous VIP in order to occupy all VIP receptors; the motor inhibitory action of VIP was counteracted by vasopressin.
VIP Binding (counteracted) of in nerve
8) Confidence 0.31 Published 1982 Journal Regul. Pept. Section Abstract Doc Link 7063753 Disease Relevance 0 Pain Relevance 0.12
Slices were used in order to preserve the physicochemical environment and the structural integrity of this heterogeneous organ. 125I-VIP binding to placental slices was saturable.
VIP Binding (binding) of
9) Confidence 0.31 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2829291 Disease Relevance 0 Pain Relevance 0
For example, it is not understood why VIP produces immunomodulatory effects at concentrations far below its receptor-binding affinity.
VIP Binding (affinity) of
10) Confidence 0.29 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8746541 Disease Relevance 0.07 Pain Relevance 0.25
In various locations of all species investigated Merkel cells were found to be immunoreactive exclusively to vasoactive intestinal polypeptide (VIP) but not to any of the other antisera used.
VIP Neg (not) Binding (immunoreactive) of in Merkel cells
11) Confidence 0.26 Published 1983 Journal J. Invest. Dermatol. Section Abstract Doc Link 6137503 Disease Relevance 0 Pain Relevance 0.47
VIP (and a fragment of its precursor named peptide his-isoleucine) acts both via hypothalamic afferents and direct paracrine and autocrine mechanisms, through lactotroph cell receptors binding, enhancing adenylate cyclase activity and increasing prolactin gene transcription.
VIP Binding (binding) of in lactotroph
12) Confidence 0.25 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.51
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
vasoactive intestinal peptide Neg (not) Binding (migration) of in neutrophil associated with somatostatin, narcan and substance p
13) Confidence 0.12 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.59
Strong evidence suggests a mechanistic link between cholesterol metabolism and the formation of amyloid-beta peptides, the principal constituents of senile plaques found in the brains of patients with Alzheimer's disease.
peptides Binding (formation) of in brains associated with alzheimer's dementia, disease and amyloid plaque
14) Confidence 0.06 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17395689 Disease Relevance 0.44 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox