INT241970

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.36 Pain Relevance 0.24

cytosol (Prkaca) nucleoplasm (Prkaca) mitochondrion (Prkaca) Golgi apparatus (Prkaca) plasma membrane (Prkaca) nucleus (Prkaca)

Anatomy Link Frequency synapses 2 Acpt (Rattus norvegicus) Prkaca (Rattus norvegicus)

Pain Link Frequency Relevance Heat depression 23 100.00 Glutamate 44 66.96 Glutamate receptor 3 50.00 noradrenaline 3 10.72 agonist 9 5.00 Action potential 7 5.00 tetrodotoxin 6 5.00 gABA 4 5.00 Calcium channel 4 5.00 Neurotransmitter 3 5.00

Disease Link Frequency Relevance Heat Depression 23 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is unlikely that PKA activation underlies the mGluR depression of eEPSCs at layer V synapses, since eEPSC amplitude was enhanced by forskolin, and the depression induced by ACPT-1 persisted in the presence of an AC inhibitor.

ACPT Positive_regulation (induced) of Positive_regulation (activation) of PKA in synapses associated with depression

1) Confidence 0.05 Published 2007 Journal Neuroscience Section Body Doc Link PMC2504724 Disease Relevance 0.36 Pain Relevance 0.24

General Comments

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