INT242137

Context Info Confidence 0.39 First Reported 2008 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 7 Total Number 8 Disease Relevance 2.99 Pain Relevance 0.67

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)

Anatomy Link Frequency nerve 2 Gsk3b (Mus musculus)

Pain Link Frequency Relevance Heat Nerve growth factor 3 98.98 Hippocampus 41 98.76 tolerance 20 94.56 adenocard 2 90.52 depression 19 82.56 positron emission tomography 8 73.52 corticosteroid 15 66.68 Serotonin 14 61.44 cytokine 4 54.00 Eae 28 51.48

Disease Link Frequency Relevance Heat Stress 41 99.32 Amyloid Plaque 22 97.20 Impaired Glucose Tolerance 15 95.20 Cognitive Disorder 132 93.60 Neuroblastoma 8 91.88 Disease 403 89.40 Attention Deficit Hyperactivity Disorder 6 87.32 Targeted Disruption 164 85.92 Depression 19 82.56 Alzheimer's Dementia 31 74.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It is possible that inactivation of GSK-3?

Spec (possible) Negative_regulation (possible) of Spec (possible) Positive_regulation (inactivation) of GSK-3

1) Confidence 0.39 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.41 Pain Relevance 0.30

Together, these data support the conclusion that the selective inactivation of GSK-3?

Negative_regulation (support) of Positive_regulation (inactivation) of GSK-3

2) Confidence 0.33 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.37 Pain Relevance 0.09

Here we demonstrate that lithium by the inhibition of GSK-3 increases ?

Negative_regulation (inhibition) of Positive_regulation (increases) of GSK-3

3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.34 Pain Relevance 0.05

Inactivation of GSK-3 increases ?

Negative_regulation (Inactivation) of Positive_regulation (increases) of GSK-3

4) Confidence 0.25 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0 Pain Relevance 0.06

Among other actions, it reduces the production of free radicals and microglia activation, stimulates the synthesis and release of the nerve growth factor, facilitates APP non-amyloidogenic processing and decreases activated GSK-3?

Negative_regulation (decreases) of Positive_regulation (activated) of GSK-3 in nerve associated with nerve growth factor

5) Confidence 0.23 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.40 Pain Relevance 0.16

reducing the activation of GSK-3?

Negative_regulation (reducing) of Positive_regulation (activation) of GSK-3

6) Confidence 0.21 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.39 Pain Relevance 0

Melatonin administration decreased oxidative stress and tau hyperphosphorylation and reversed GSK-3 activation showing thereby that it not only acts as an antioxidant but also interferes with the phosphorylation system, particularly stress kinases [91].

Negative_regulation (reversed) of Positive_regulation (activation) of GSK-3 associated with stress

7) Confidence 0.21 Published 2011 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3004402 Disease Relevance 0.74 Pain Relevance 0

-catenin and inhibits the increase in GSK-3?

Negative_regulation (inhibits) of Positive_regulation (increase) of GSK-3

8) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 0.35 Pain Relevance 0.03

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