INT24238

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.97
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Syn1) ligase activity (Syn1)
Anatomy Link Frequency
neurons 2
neuronal 1
brain 1
synaptic vesicles 1
Syn1 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 13 96.16 Very High Very High Very High
Neurotransmitter 39 94.88 High High
Kinase C 246 93.92 High High
Neuronal excitability 17 91.20 High High
Spinal cord 7 82.44 Quite High
tetrodotoxin 14 74.96 Quite High
Lasting pain 1 71.48 Quite High
nMDA receptor 10 71.40 Quite High
Enkephalin 1 65.64 Quite High
long-term potentiation 24 59.20 Quite High
Disease Link Frequency Relevance Heat
Infection 60 98.40 Very High Very High Very High
Virus Diseases 282 98.00 Very High Very High Very High
Depression 13 96.16 Very High Very High Very High
Cancer 2 95.72 Very High Very High Very High
Injury 3 91.16 High High
Convulsion 68 86.80 High High
Frailty 2 82.72 Quite High
Death 32 80.84 Quite High
Adhesions 5 77.76 Quite High
Targeted Disruption 103 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we show that transplantation of pre-differentiated ES cells activate both brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) signaling pathways in the host tissue, leading to activation of cAMP/PKA, phosporylation of cofilin and synapsin I, and promoting regenerative growth and neuronal survival.
Phosphorylation (phosporylation) of synapsin I in neuronal
1) Confidence 0.45 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19138107 Disease Relevance 0.41 Pain Relevance 0.15
Consistent with the analysis of synapsin I phosphorylation at site 1 (Figure 4C), we observed that forskolin enhanced SV recycling to the same extent in control and BDV-infected neurons (Figure 5B).
Phosphorylation (phosphorylation) of synapsin I in neurons associated with virus diseases
2) Confidence 0.12 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.62 Pain Relevance 0.42
In addition, staining for synapsin I phosphorylated at either site 3 or site 1, two sites specific for CaMK II and PKA/CaMK I, respectively [30], showed that BDV did not interfere with signaling by these kinases (Figure 4B and 4C).
Phosphorylation (phosphorylated) of synapsin I associated with virus diseases
3) Confidence 0.12 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.72 Pain Relevance 0.17
Antibodies specific for synapsin I phosphorylated by CaMK II at site 3 (clone RU19), or by PKA and CaMK I at site 1 (clone G257) were provided by P.
Phosphorylation (phosphorylated) of synapsin I
4) Confidence 0.12 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.10 Pain Relevance 0.39
may act via phosphorylation of synapsin in mice and we indeed observed an influence of TGF-?
Phosphorylation (phosphorylation) of synapsin
5) Confidence 0.12 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
1 stimulates MAPK-dependent phosphorylation of synapsin, which in turn modulates synapsin distribution, and results in a reduced magnitude of synaptic depression [9].
Phosphorylation (phosphorylation) of synapsin associated with depression
6) Confidence 0.09 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0.33 Pain Relevance 0.05
on the phosphorylation of synapsin in hippocampal neurons (unpublished observation).
Phosphorylation (phosphorylation) of synapsin in neurons
7) Confidence 0.09 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
Synapsin phosphorylation is a crucial event for the dissociation of synapsin from synaptic vesicles during normal vesicle cycling [40] and the subsequent release of synaptic vesicles from the actin-bound reserve pool into the readily releasable pool of vesicles.
Phosphorylation (phosphorylation) of Synapsin in synaptic vesicles
8) Confidence 0.09 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
A mechanism involving the phosphorylation of synapsin has been shown for brain-derived neurotrophic factor [41] and was also discussed for the chordin-/- mouse mutant, which has increased BMP signaling [42].
Phosphorylation (phosphorylation) of synapsin in brain
9) Confidence 0.09 Published 2008 Journal Neural Develop Section Body Doc Link PMC2576228 Disease Relevance 0 Pain Relevance 0.04
Cdk5 has specifically been implicated in exocytosis and endocytosis via phosphorylation of numerous substrates including synapsin, amphiphysin I, dynamin, and others [44]–[47].
Phosphorylation (phosphorylation) of synapsin
10) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695674 Disease Relevance 0.62 Pain Relevance 0.23
Neither the 90-kDa nor the 80-kDa protein showed any immunological cross-reactivity with synapsin, a major synaptic protein known to be phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase, but not calcium/phospholipid-dependent protein kinase.
Phosphorylation (phosphorylated) of synapsin
11) Confidence 0.04 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 2450174 Disease Relevance 0.18 Pain Relevance 0.07

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