INT242635

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.98
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk3) extracellular region (Bdnf) plasma membrane (Ntrk3)
cytoplasmic membrane-bounded vesicle (Bdnf) kinase activity (Ntrk3) cytoplasm (Ntrk3)
Anatomy Link Frequency
synapse 2
brain 1
Bdnf (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 3 100.00 Very High Very High Very High
Nerve growth factor 33 99.98 Very High Very High Very High
Hippocampus 91 80.00 Quite High
Peripheral nervous system 1 73.92 Quite High
Central nervous system 19 57.04 Quite High
Glutamate 234 55.40 Quite High
depression 73 50.00 Quite Low
Neurotransmitter 15 50.00 Quite Low
long-term potentiation 4 27.12 Quite Low
Neuropeptide 7 18.72 Low Low
Disease Link Frequency Relevance Heat
Adhesions 17 95.28 Very High Very High Very High
Congenital Anomalies 9 80.36 Quite High
Targeted Disruption 176 78.80 Quite High
Nervous System Malformation 16 74.00 Quite High
Ganglion Cysts 66 70.96 Quite High
Hyperplasia 1 51.52 Quite High
Depression 95 50.00 Quite Low
Mental Disorders 6 35.12 Quite Low
Suicidal Behaviour 123 31.40 Quite Low
Stress 73 20.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spine growth and synapse formation is also regulated by neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF), and the respective receptors for these neurotrophic factors, such as NTRK2 and NTRK3 [42,43].
Brain-Derived Neurotrophic Factor Binding (receptors) of NTRK3 in synapse
1) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.39 Pain Relevance 0.09
Spine growth and synapse formation is also regulated by neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF), and the respective receptors for these neurotrophic factors, such as NTRK2 and NTRK3 [42,43].
BDNF Binding (receptors) of NTRK3 in synapse
2) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.39 Pain Relevance 0.07
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
BDNF Binding (binds) of TrkC associated with nerve growth factor
3) Confidence 0.08 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.19
Modified from Airaksinen and Saarma (2002). b The neurotrophins, viz. nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3) bind with high affinity to the tyrosine kinase receptors trkA, trkB and trkC, respectively.
brain-derived neurotrophic factor Binding (bind) of trkC in brain associated with neurotrophin 3 and nerve growth factor
4) Confidence 0.07 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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