INT242883

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.35
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS) intracellular (TLR2) carbohydrate metabolic process (INS)
cytoplasm (TLR2) cell-cell signaling (INS) signal transduction (TLR2)
INS (Homo sapiens)
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 99.36 Very High Very High Very High
metalloproteinase 2 85.60 High High
cytokine 2 84.40 Quite High
ischemia 6 84.16 Quite High
Inflammatory response 6 65.32 Quite High
Inflammatory mediators 2 10.80 Low Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 46 99.36 Very High Very High Very High
Bacterial Infection 2 98.80 Very High Very High Very High
Endotoxemia 4 98.08 Very High Very High Very High
Infection 4 95.60 Very High Very High Very High
Rupture 2 91.44 High High
Atherosclerosis 16 89.24 High High
Cv Unclassified Under Development 6 84.16 Quite High
Reperfusion Injury 2 83.44 Quite High
Atherosclerotic Plaque 2 82.12 Quite High
Shock 4 79.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The suppression of TLR2 expression at mRNA and protein level by insulin is relevant to gram-positive bacterial infections.
insulin Negative_regulation (suppression) of Gene_expression (expression) of TLR2 associated with bacterial infection
1) Confidence 0.17 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 0.94 Pain Relevance 0.36
The rapid suppression of TLR2 and TLR4 expression by insulin implies that insulin can be used clinically in endotoxemia and gram-negative (TLR4) and gram-positive (TLR2) infections to limit their inflammatory effects.
insulin Negative_regulation (suppression) of Gene_expression (expression) of TLR2 associated with endotoxemia, inflammation and infection
2) Confidence 0.13 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.41 Pain Relevance 0.24

General Comments

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