INT242949

Context Info Confidence 0.68 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.05 Pain Relevance 0.13

cytosol (PDE5A) signal transduction (PDE5A) cellular_component (PDE5A)

PDE5A (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 13 88.64 Neurotransmitter 8 61.00 Angina 2 52.56 Inflammation 42 10.84 long-term potentiation 17 5.00 Hippocampus 9 5.00 Multiple sclerosis 7 5.00 Inflammatory mediators 4 5.00 Pain 3 5.00 headache 3 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 2 52.56 Reprotox - General 2 12 20.00 INFLAMMATION 48 10.84 Natriuresis 3 9.20 Pulmonary Disease 31 5.00 Disease 26 5.00 Neurodegenerative Disease 20 5.00 Demyelinating Disease 7 5.00 Pressure And Volume Under Development 7 5.00 Increased Venous Pressure Under Development 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Moreover, PKG is an excellent in vitro catalyst for the phosphorylation of PDE5 (Thomas et al 1990).

Phosphorylation (phosphorylation) of PDE5

1) Confidence 0.68 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.05 Pain Relevance 0.13

Allosteric binding of cGMP to PDE5 regulatory domain increases affinity of the catalytic site for cGMP, thereby stimulating the rate of cGMP hydrolysis (Thomas et al 1990b; Mullershausen et al 2001; Okada and Asakawa 2002; Corbin et al 2003; Rybalkin et al 2003). cGMP binding to the regulatory domain also stimulates phosphorylation of PDE5 by cGMP-dependent protein kinase (Thomas et al 1990b; Wyatt et al 1998; Mullershausen et al 2001; Murthy 2001; Rybalkin et al 2002b). cGMP binding to these sites must be preceded by occupation of the catalytic site by cGMP (Francis et al 1980; Thomas et al 1990b) and it appears that cGMP binding to the regulatory domain produces a conformational change in PDE5 that exposes Ser-92 allowing phosphorylation which increases affinity of the regulatory domain for cGMP and increases catalytic activity as well (Corbin et al 2000).

Phosphorylation (phosphorylation) of PDE5

2) Confidence 0.14 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0

General Comments

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