INT242969

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Context Info
Confidence 0.68
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.94
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Calr) Golgi apparatus (Calr) endoplasmic reticulum (Calr)
cytoplasm (Calr) cytosol (Calr) protein folding (Calr)
Anatomy Link Frequency
CPA 1
arm 1
Calr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 50.08 Quite High
cytokine 2 34.44 Quite Low
Calcium channel 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 35 92.88 High High
American Trypanosomiasis 16 92.04 High High
Obesity 47 88.36 High High
Cancer 10 72.08 Quite High
Necrosis 3 71.60 Quite High
Insulin Resistance 9 51.92 Quite High
INFLAMMATION 5 50.08 Quite High
Ovarian Cancer 1 18.48 Low Low
Metastasis 1 8.96 Low Low
Coronary Heart Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study whether cytosolic TcCRT was degraded by the proteasome, retrotranslocation was stimulated by CPA in the presence of the proteasome inhibitor MG132.
Protein_catabolism (degraded) of TcCRT in CPA
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Lower cytosolic TcCRT levels were observed in the presence of cycloheximide, thus suggesting that TcCRT was being degraded in the cytosol.


Protein_catabolism (degraded) of TcCRT
2) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
Cytosolic CRT was subsequently degraded by the proteasome.
Protein_catabolism (degraded) of CRT
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2950133 Disease Relevance 0.17 Pain Relevance 0
Cytosolic TcCRT is degraded by the proteasome
Protein_catabolism (degraded) of TcCRT
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950133 Disease Relevance 0 Pain Relevance 0
In addition, the CNX/CRT cycle is one arm of the quality-control machinery in the ER that monitors the glycosylation status of proteins and determines whether a molecule is exported to the Golgi complex or targeted for ER-associated degradation (14,19).
Protein_catabolism (degradation) of CRT in arm
5) Confidence 0.09 Published 2008 Journal Diabetes Section Body Doc Link PMC2518495 Disease Relevance 0.78 Pain Relevance 0.03

General Comments

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