INT243112

From wiki-pain
Revision as of 17:01, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.14
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Rpe) carbohydrate metabolic process (Rpe)
Anatomy Link Frequency
choroid 2
eye 1
photoreceptor 1
glial cells 1
Rpe (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 36 75.52 Quite High
Glutamate 29 5.00 Very Low Very Low Very Low
Eae 24 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
nMDA receptor 9 5.00 Very Low Very Low Very Low
ketamine 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
dopamine receptor 6 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 6 99.88 Very High Very High Very High
Disease 19 99.68 Very High Very High Very High
Age-related Macular Degeneration 51 99.00 Very High Very High Very High
Hyperuricemia 1 98.08 Very High Very High Very High
Hyperlipidemia 2 97.78 Very High Very High Very High
Diabetes Mellitus 13 97.02 Very High Very High Very High
Geographic Atrophy 2 96.88 Very High Very High Very High
Aging 11 94.36 High High
Apoptosis 55 93.00 High High
Injury 26 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is important to mention that these data do not define the contribution of the SCN to the regulation of the circadian rhythms in the RPE in vivo.
Regulation (regulation) of RPE
1) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0.03
Our data indicate that the PER2::LUC bioluminescence rhythm in the RPE-choroid is not affected by SCN lesions, implying that the mechanisms controlling PER2::LUC bioluminescence in the mouse RPE-choroid reside within the eye.
Neg (not) Regulation (affected) of RPE-choroid in eye
2) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0.04
We believe that these results indicate the value of designing studies aimed at elucidating the molecular mechanisms responsible for the regulation of the rhythmic event in the RPE.



Regulation (regulation) of RPE
3) Confidence 0.40 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
The results from this study suggest that cigarette smoke plays a role in RPE changes associated with AMD.
Regulation (role) of RPE associated with age-related macular degeneration
4) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2518621 Disease Relevance 1.18 Pain Relevance 0
Finally, removal of the suprachiasmatic nuclei of the hypothalamus did not affect the bioluminescence circadian rhythm in the RPE-choroid.


Neg (not) Regulation (affect) of RPE-choroid in choroid
5) Confidence 0.18 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
Our data are consistent with these results (Figure 1D and Figure 2C) and expand on the previous investigations by showing that Per2 gene expression is under circadian control in the RPE in vivo, and that isolated RPE-choroid explants can express a long-lasting circadian rhythm in PER2::LUC bioluminescence.
Regulation (control) of RPE in choroid
6) Confidence 0.18 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0.06 Pain Relevance 0.03
These new data indicate that it may be useful to design studies with the aim of elucidating the molecular mechanisms responsible for the regulation of the rhythmic event in the RPE.



Regulation (regulation) of RPE
7) Confidence 0.18 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0
However, most studies have focused on diseases that primarily affect the photoreceptor, RPE, and RGC layer.
Regulation (affect) of RPE in photoreceptor associated with disease
8) Confidence 0.13 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2713732 Disease Relevance 1.00 Pain Relevance 0
Although care must be taken in extrapolating results in mice to humans, particularly under pathological conditions, our results suggest that it is safe to re-administer AAV vectors into the subretinal space to target PR and RPE cells without compromising the efficacy of the repeated gene transfers.



Regulation (target) of RPE
9) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2633462 Disease Relevance 0 Pain Relevance 0
On the other hand all other systemic metabolic problems of the organism like diabetes mellitus, hyperlipidemia, hypercholesterolemia, hyperuricemia, high systemic blood pressure and periods of very low perfusion pressure due to vasospasm also affect the microenvironment of the RGCs and RPE – from the capillaries via the extracellular space via the glial cells down to the intracellular “milieu” of these neurons.
Regulation (affect) of RPE in glial cells associated with hyperuricemia, diabetes mellitus, increased venous pressure under development and hyperlipidemia
10) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.90 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox