INT243156

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (P2rx7, NOS1) transport (P2rx7) cell morphogenesis (P2rx7)
mitochondrion organization (P2rx7) protein complex (P2rx7) transmembrane transport (P2rx7)
Anatomy Link Frequency
astrocytes 2
P2rx7 (Mus musculus)
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 5 82.44 Quite High
depression 3 76.72 Quite High
Neurotransmitter 10 34.72 Quite Low
Action potential 2 19.36 Low Low
imagery 8 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
GABAergic 3 5.00 Very Low Very Low Very Low
nMDA receptor 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
GABA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 3 76.72 Quite High
Vibrio Infection 2 5.00 Very Low Very Low Very Low
Hypothermia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide is a highly probable candidate because (a) P2 receptor activation induces nitric oxide synthase in many cell types (Ohtani et al., 2000; Auld and Robitaille, 2003; Silva et al., 2006); (b) astrocytes are endowed with nitric oxide synthase (Murphy, 2000; Kozuka et al., 2007) and they can produce nitric oxide in response to activation by various agents including ATP (Li et al., 2003; Murakami et al., 2003); (c) NO is a membrane-permeable molecule that can diffuse from astrocytes to neurons; and (e), lastly but most importantly, NO is the prevailing mediator of plastic changes in synaptic transmission implicated in long term potentiation (Wang et al., 2004) and long term depression (Stanton et al., 2003).
Positive_regulation (activation) of P2 receptor in astrocytes Positive_regulation (induces) of oxide synthase associated with depression
1) Confidence 0.00 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0.08 Pain Relevance 0.08

General Comments

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