INT243487

Context Info Confidence 0.07 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.79

cytosol (Calb1) nucleus (Calb1) intracellular (Calb1) cytoplasm (Calb1)

Anatomy Link Frequency shell 1 neurons 1 Calb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Nucleus accumbens 292 99.40 Pyramidal cell 336 66.56 Hippocampus 6 5.00 GABAergic 6 5.00 anesthesia 4 5.00 Dopamine 4 5.00 Somatostatin 4 5.00 cerebral cortex 2 5.00 ketamine 2 5.00 withdrawal 2 5.00

Disease Link Frequency Relevance Heat Increased Venous Pressure Under Development 2 5.00 Volume Depletion And Dehydration 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To differentiate between the Acb shell and core subregions, as well as between the compartments therein, we employed the immunoreactivity patterns of the calcium-binding protein calbindin-D28 kDa (CaB) as an established maker (Fig. 2).

calbindin-D28 kDa Binding (binding) of in shell associated with nucleus accumbens

1) Confidence 0.07 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.26

Fig. 2Overview of the location and dendritic orientation of neurobiotin-injected neurons in the nucleus accumbens (Acb) represented in eight equally spaced horizontal sections that are ‘counterstained’ for the calcium-binding protein calbindin-D28 kDa to reveal the Acb shell and core subregions.

calbindin-D28 kDa Binding (binding) of in neurons associated with nucleus accumbens

2) Confidence 0.05 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522331 Disease Relevance 0 Pain Relevance 0.53

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