INT2435

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Context Info
Confidence 0.58
First Reported 1979
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 3.32
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
liver 2
brain 1
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 28 100.00 Very High Very High Very High
Potency 6 100.00 Very High Very High Very High
lidocaine 6 99.62 Very High Very High Very High
Mexiletine 7 99.56 Very High Very High Very High
mu opioid receptor 4 99.36 Very High Very High Very High
Bioavailability 5 98.08 Very High Very High Very High
cINOD 6 97.04 Very High Very High Very High
Inflammation 15 96.84 Very High Very High Very High
fluoxetine 7 96.80 Very High Very High Very High
depression 5 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Appetite Loss 2 100.00 Very High Very High Very High
Body Weight 1 100.00 Very High Very High Very High
INFLAMMATION 15 96.84 Very High Very High Very High
Cancer 34 96.72 Very High Very High Very High
Depression 5 96.40 Very High Very High Very High
Hepatotoxicity 6 95.80 Very High Very High Very High
Arthritis 2 91.80 High High
Pain 3 91.24 High High
Overdose 3 87.68 High High
Necrosis 5 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicate that cysteamine increases heme oxygenase activity in rat liver, with a subsequent decrease in total heme, AHH activity, and cytochrome P-450 content.
Negative_regulation (decrease) of AHH in liver
1) Confidence 0.58 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2609341 Disease Relevance 0.44 Pain Relevance 0.41
Two microsomal enzyme activities (ethoxyresorufin-O-deethylase, EROD; aryl-hydrocarbon-hydroxylase, AHH) were also decreased.
Negative_regulation (decreased) of AHH
2) Confidence 0.57 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.49 Pain Relevance 0.47
Cytochrome P450 I (EROD activity) was decreased to 35-44% of control values by the ether anaesthesia and was restored to 80% of normal levels 2 h later. 5.
Negative_regulation (decreased) of Cytochrome P450 I
3) Confidence 0.47 Published 1991 Journal Xenobiotica Section Abstract Doc Link 2058176 Disease Relevance 0.07 Pain Relevance 0
Relative potency of mexiletine, lidocaine, and tocainide as inhibitors of rat liver CYP1A1 activity.
Negative_regulation (inhibitors) of CYP1A1 in liver associated with mexiletine, lidocaine and potency
4) Confidence 0.43 Published 1995 Journal Drug Metab. Dispos. Section Title Doc Link 8689940 Disease Relevance 0 Pain Relevance 0.86
Administration of cysteamine to rats depressed hepatic aryl hydrocarbon hydroxylase (AHH) activity, cytochrome P-450, and total heme at 24 hr.
Negative_regulation (depressed) of AHH
5) Confidence 0.42 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2609341 Disease Relevance 0.13 Pain Relevance 0.07
Two microsomal enzyme activities (ethoxyresorufin-O-deethylase, EROD; aryl-hydrocarbon-hydroxylase, AHH) were also decreased.
Negative_regulation (decreased) of aryl-hydrocarbon-hydroxylase
6) Confidence 0.40 Published 1998 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 10323327 Disease Relevance 0.49 Pain Relevance 0.48
Administration of cysteamine to rats depressed hepatic aryl hydrocarbon hydroxylase (AHH) activity, cytochrome P-450, and total heme at 24 hr.
Negative_regulation (depressed) of aryl hydrocarbon hydroxylase
7) Confidence 0.37 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2609341 Disease Relevance 0.13 Pain Relevance 0.07
The glutathione S-transferase and aryl hydrocarbon hydroxylase activities were decreased in castrated male rats, whereas epoxide hydratase activity was unaltered.
Negative_regulation (decreased) of hydrocarbon hydroxylase
8) Confidence 0.36 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.55
Interestingly, Te-phenyl-L-tellurocysteine selectively inhibited cytochrome P450 1A1 directly, which is, for example, responsible for the activation of several procarcinogens.
Negative_regulation (inhibited) of cytochrome P450 1A1
9) Confidence 0.30 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482244 Disease Relevance 0 Pain Relevance 0.08
Fluvoxamine inhibits with decreasing potency, CYP1A2, CYP2C19, CYP2D6 and CYP1A1, but it is also an inhibitor of CYP3A.
Negative_regulation (decreasing) of CYP1A1 associated with potency
10) Confidence 0.05 Published 1996 Journal Clin Pharmacokinet Section Abstract Doc Link 8968657 Disease Relevance 0.25 Pain Relevance 1.17
The present study was undertaken to assess if hypothalamic beta-endorphin (beta E) and/or brain mu opioid receptors are associated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) (50 micrograms/kg)-induced hypophagia and body weight decline in rats.
Negative_regulation (decline) of tetrachlorodibenzo-p-dioxin in brain associated with appetite loss, body weight and mu opioid receptor
11) Confidence 0.05 Published 1991 Journal Neurotoxicol Teratol Section Abstract Doc Link 1661835 Disease Relevance 0.20 Pain Relevance 0.16
Nevertheless, when culturing the cells for a further 48 h, a decrease in glutathione levels, albumin synthesis, CYP1A activity, DNA content and mitochondrial function was apparent.
Negative_regulation (decrease) of CYP1A
12) Confidence 0.04 Published 1999 Journal J. Hepatol. Section Body Doc Link 10580581 Disease Relevance 0.07 Pain Relevance 0
This was accompanied by a significant reduction in hepatic cytochrome P450, CYP3A, and CYP1A content as well as significantly reduced verapamil free fraction in pre-AA.
Negative_regulation (reduction) of CYP1A
13) Confidence 0.03 Published 2005 Journal Drug Metab. Dispos. Section Abstract Doc Link 15659540 Disease Relevance 0.78 Pain Relevance 0.54
Pterostilbene and related compounds inhibit the cytochrome P450 enzymes, CYP1A1 and CYP1B1, which induce carcinogenicity of environmental teratogens [5].
Negative_regulation (inhibit) of CYP1A1
14) Confidence 0.02 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2532997 Disease Relevance 0.18 Pain Relevance 0.08
Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse.
Negative_regulation (depletion) of microsomal monooxygenase associated with paracetamol
15) Confidence 0.01 Published 1993 Journal Xenobiotica Section Title Doc Link 8237062 Disease Relevance 0.10 Pain Relevance 0.20

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