INT243639

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) extracellular space (Il2) extracellular region (Il2)
nucleus (Twist1) DNA binding (Twist1) transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 2
Twist1 (Mus musculus)
Il2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 46 100.00 Very High Very High Very High
chemokine 8 94.20 High High
Crohn's disease 14 90.48 High High
rheumatoid arthritis 8 83.92 Quite High
Inflammation 82 72.44 Quite High
Arthritis 30 60.72 Quite High
Inflammatory response 2 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 16 92.64 High High
Adhesions 2 92.32 High High
Apoptosis 4 90.72 High High
Disease 28 89.84 High High
Rheumatoid Arthritis 12 83.92 Quite High
INFLAMMATION 84 72.44 Quite High
Hypersensitivity 28 64.16 Quite High
Arthritis 26 60.72 Quite High
Diabetes Mellitus 2 37.64 Quite Low
Targeted Disruption 2 28.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of relevance for the effector function of Th1 EM cells, twist1 attenuated expression of the effector cytokine genes il-2, ifn-?
twist1 Negative_regulation (attenuated) of Gene_expression (expression) of il-2 associated with cytokine
1) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.24 Pain Relevance 0.31
Twist1 reduces the functionality of Th1 cells by attenuating expression of IL-2, TNF-?
Twist1 Negative_regulation (attenuating) of Gene_expression (expression) of IL-2 in Th1 cells
2) Confidence 0.24 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 1.04 Pain Relevance 0.35

General Comments

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