INT243768

Context Info Confidence 0.47 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0

nucleus (Egr2, Nab2) intracellular (Egr2) DNA binding (Egr2) transcription factor binding (Nab2) ligase activity (Egr2) cytoplasm (Egr2)

Anatomy Link Frequency Schwann cells 2 Egr2 (Mus musculus) Nab2 (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 10 10.20 long-term potentiation 8 5.00 dopamine receptor 2 5.00 Central nervous system 2 5.00 withdrawal 2 5.00 opiate 2 5.00 amygdala 2 5.00 Eae 2 5.00 cerebral cortex 1 5.00 Pyramidal cell 1 5.00

Disease Link Frequency Relevance Heat Repression 2 82.68 Cognitive Disorder 20 33.24 Anxiety Disorder 20 5.00 Shock 20 5.00 Targeted Disruption 9 5.00 Appetite Loss 8 5.00 Convulsion 4 5.00 Peripheral Neuropathy 3 5.00 Brain Hemorrhage 2 5.00 Body Weight 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Consistent with this, Egr2 was shown to positively regulate the expression of Nab1 and Nab2 in the developing hindbrain (Mechta-Grigoriou et al., 2000, Desmazières, Charnay and Gilardi-Hebenstreit, unpublished data), and a gene expression profiling study in Schwann cells has identified Nab2 as a target of Egr2 (Nagarajan et al., 2001).

Egr2 Regulation (regulate) of Gene_expression (expression) of Nab2 in Schwann cells

1) Confidence 0.47 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525857 Disease Relevance 0.14 Pain Relevance 0

General Comments

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