INT243912

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Nlgn2) plasma membrane (Nlgn2)
Anatomy Link Frequency
synapses 1
Nlgn2 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 3 85.04 High High
GABAergic 29 82.24 Quite High
Glutamate receptor 15 67.92 Quite High
Spinal cord 1 40.00 Quite Low
nMDA receptor 7 12.24 Low Low
gABA 28 5.00 Very Low Very Low Very Low
Neurotransmitter 13 5.00 Very Low Very Low Very Low
Glutamate 11 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Respiratory Failure 1 80.44 Quite High
Targeted Disruption 13 75.00 Quite High
Generalized Anxiety Disorder 2 59.68 Quite High
Schizophrenia 13 50.00 Quite Low
Adhesions 2 30.64 Quite Low
Disease 12 17.76 Low Low
Depression 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, we observed that the two-step procedure unmasked core interacting proteins that were not detected by mass spectrometry in the single-step purification: Ten known PSD-95 interactors, Begain, Cit, Grik2, Grik5, Grin2c, Kcna4, Lrp1, Nlgn2, Nlgn3 and Shank1, were present only after the tandem purification.
Gene_expression (present) of Nlgn2
1) Confidence 0.37 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0 Pain Relevance 0.03
Overexpression or deletion of neuroligins enhances or respectively decreases synaptic responses (neuroligin-1 for excitatory synapses, neuroligin-2 for inhibitory synapses), but the effect is activity dependent.
Gene_expression (synapses) of neuroligin-2 in synapses
2) Confidence 0.10 Published 2008 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2526003 Disease Relevance 0.22 Pain Relevance 0.08

General Comments

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