INT24406

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 0.46
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htr5a) plasma membrane (Htr5a) signal transducer activity (Htr5a)
Anatomy Link Frequency
brain 2
5-HT neurons 1
amygdala 1
Htr5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 20 99.84 Very High Very High Very High
Dopamine 12 99.80 Very High Very High Very High
Raphe 4 99.72 Very High Very High Very High
anesthesia 2 98.88 Very High Very High Very High
agonist 2 96.92 Very High Very High Very High
Morphine 12 93.80 High High
Action potential 2 89.28 High High
spinal dorsal horn 76 86.76 High High
monoamine 2 85.92 High High
Spinal cord 6 84.56 Quite High
Disease Link Frequency Relevance Heat
Nociception 40 86.08 High High
INFLAMMATION 70 84.36 Quite High
Nervous System Injury 2 32.96 Quite Low
Pain 20 30.16 Quite Low
Injury 10 10.64 Low Low
Generalized Anxiety Disorder 4 7.00 Low Low
Hypersensitivity 10 5.00 Very Low Very Low Very Low
Hyperalgesia 8 5.00 Very Low Very Low Very Low
Hypoalagesia 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, at the baseline, the expressions of the gene coding for 5-HT5a receptor, although upregulated vs.
Gene_expression (expressions) of 5-HT5a
1) Confidence 0.58 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.15 Pain Relevance 0.14
Several classes of 5-HT and dopamine (DA) receptor binding sites, and the levels of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), DA and dihydroxyphenylacetic acid (DOPAC) were examined in various brain regions 24 h after a 10-day treatment with morphine (2 X 15 mg/kg s.c. daily) in adult rats.
Spec (examined) Gene_expression (levels) of 5-HT in brain associated with dopamine and morphine
2) Confidence 0.38 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.55
The next group of eight genes encodes eight 5-HT serotonergic receptors (5-HT1a, 5-HT1d, 5-HT1e, 5-HT1f, 5-HT2c, 5-HT4, 5-HT5a, and 5-HT6).
Gene_expression (encodes) of 5-HT5a
3) Confidence 0.29 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.30 Pain Relevance 0.34
Several classes of 5-HT and dopamine (DA) receptor binding sites, and the levels of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), DA and dihydroxyphenylacetic acid (DOPAC) were examined in various brain regions 24 h after a 10-day treatment with morphine (2 X 15 mg/kg s.c. daily) in adult rats.
Spec (examined) Gene_expression (classes) of 5-HT in brain associated with dopamine and morphine
4) Confidence 0.22 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2456939 Disease Relevance 0 Pain Relevance 0.54
Apamin increases 5-HT cell firing in raphe dorsalis and extracellular 5-HT levels in amygdala: a concomitant in vivo study in anesthetized rats.
Gene_expression (levels) of extracellular 5-HT in amygdala associated with anesthesia, amygdala and raphe
5) Confidence 0.12 Published 2009 Journal Brain Res. Section Title Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.50
Increases of extracellular 5-HT levels in the amygdala were also seen when apamin was microinjected into the RDN, suggesting a role for 5-HT neurons of the RDN as target for subcutaneously administered apamin.
Gene_expression (levels) of extracellular 5-HT in 5-HT neurons associated with amygdala
6) Confidence 0.12 Published 2009 Journal Brain Res. Section Abstract Doc Link 19446538 Disease Relevance 0 Pain Relevance 0.50

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