INT244232

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Context Info
Confidence 0.17
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.48
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ccr5) cell-cell signaling (Ccr5) cytoplasm (Ccr5)
signal transducer activity (Ccr5) signal transduction (Ccr5) extracellular space (Ccl4)
Anatomy Link Frequency
macrophage 1
Ccr5 (Mus musculus)
Ccl4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 79 99.52 Very High Very High Very High
antagonist 22 92.24 High High
cytokine 49 76.08 Quite High
Arthritis 9 74.84 Quite High
rheumatoid arthritis 7 67.08 Quite High
Inflammation 72 47.40 Quite Low
corticosteroid 13 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 107 97.88 Very High Very High Very High
Chlamydia Infection 67 95.28 Very High Very High Very High
INFLAMMATION 74 93.84 High High
Targeted Disruption 4 84.20 Quite High
Infection 31 80.76 Quite High
Arthritis 8 74.84 Quite High
Rheumatoid Arthritis 7 67.08 Quite High
Dyspnea 1 50.32 Quite High
Bacterial Meningitis 1 18.64 Low Low
Apoptosis 5 11.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCL3 and CCL4 are also CCR5 ligands, but these chemokines were not remarkably elevated compared to CCL5, which was the most abundant CCR5 ligand expressed during the early stages (i.e., < 7 days) of chlamydial infection.
CCR5 Binding (ligands) of CCL4 associated with chemokine and chlamydia infection
1) Confidence 0.17 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2543025 Disease Relevance 0.67 Pain Relevance 0.16
The IC50 values reported for the inhibition of receptor binding, 0.015 nM for CCL3 binding to CCR1 and 3 nM for CCL4 binding to CCR5 (11), are reflected by the ability of Evasin-1 to inhibit the chemotactic activity of these chemokines in vitro and in vivo.
CCR5 Binding (binding) of CCL4 associated with chemokine
2) Confidence 0.10 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2526197 Disease Relevance 0.09 Pain Relevance 0.13
However, these drugs are unable to significantly reduce macrophage chemoattraction because they inhibit only CCL3, but not CCL4 binding to CCR5, thus probably not being of particular interest for COPD treatment.


CCR5 Binding (binding) of CCL4 in macrophage associated with pulmonary disease
3) Confidence 0.04 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.72 Pain Relevance 0.26

General Comments

This test has worked.

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