INT244389

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.40 Pain Relevance 0.20

plasma membrane (Slc12a2)

Slc12a2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory mediators 46 94.96 Inflammatory stimuli 2 75.76 Inflammation 18 5.00 gABA 15 5.00 Hyperalgesia 12 5.00 nociceptor 12 5.00 substance P 10 5.00 Neuropeptide 6 5.00 imagery 5 5.00 GABAergic 5 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 66 94.96 Ganglion Cysts 2 50.00 Hyperalgesia 12 5.00 Nociception 12 5.00 Neuropathic Pain 5 5.00 Peripheral Arterial Disease 4 5.00 Pain 2 5.00 Neurogenic Inflammation 2 5.00 Neurological Disease 1 5.00 Epilepsy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This observation suggests that the enhanced Cl- accumulation is not the consequence of transcriptional upregulation of NKCC1 or the downregulation of KCC2 transcription.

Negative_regulation (downregulation) of Positive_regulation (upregulation) of NKCC1

1) Confidence 0.40 Published 2008 Journal Mol Pain Section Body Doc Link PMC2526990 Disease Relevance 0.40 Pain Relevance 0.20

General Comments

This test has worked.