INT244559

Context Info Confidence 0.35 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.56 Pain Relevance 0.12

cytosol (EIF2S2) RNA binding (EIF2S2) translation factor activity, nucleic acid binding (EIF2S2) translation (EIF2S2)

Anatomy Link Frequency A549 4 EIF2S2 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 4 88.28 Nicotine 36 5.00 Inflammation 20 5.00 COX-2 inhibitor 4 5.00 cINOD 4 5.00 Inflammatory response 4 5.00

Disease Link Frequency Relevance Heat Stress 268 99.78 Malignant Neoplastic Disease 80 79.44 Cancer 160 77.92 Disease 28 77.24 Apoptosis 32 54.56 Lung Cancer 188 5.00 Nicotine Addiction 120 5.00 Hypoxia 48 5.00 Carcinoma 48 5.00 Non-small-cell Lung Cancer 36 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Figure 2, PERK siRNA transfected A549 cells show notably reduced phosphorylation of eIF2?

Negative_regulation (reduced) of Phosphorylation (phosphorylation) of eIF2 in A549

1) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0.04

The suppression of protein translation via phosphorylation of both PERK and eIF2?

Negative_regulation (suppression) of Phosphorylation (phosphorylation) of eIF2

2) Confidence 0.35 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.39 Pain Relevance 0

In addition to transiently suppressing protein translation during ER stress, a second function of PERK phosphorylation of eIF2?

Negative_regulation (function) of Phosphorylation (phosphorylation) of eIF2 associated with stress

3) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.42 Pain Relevance 0.04

As shown in Figure 2, PERK siRNA transfected A549 cells show notably reduced phosphorylation of eIF2?

Negative_regulation (show) of Phosphorylation (phosphorylation) of eIF2 in A549

4) Confidence 0.25 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.38 Pain Relevance 0.04

General Comments

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