INT244674

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp16) extracellular region (Mmp16) proteinaceous extracellular matrix (Mmp16)
plasma membrane (Mmp16)
Anatomy Link Frequency
lung 4
Mmp16 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 18 99.02 Very High Very High Very High
metalloproteinase 20 50.00 Quite Low
fibrosis 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperoxia 14 98.66 Very High Very High Very High
Birth Weight 10 94.24 High High
Bronchopulmonary Dysplasia 122 92.32 High High
Genetic Predisposition To Disease 6 85.52 High High
Respiratory Disease 4 42.72 Quite Low
Pulmonary Disease 8 40.16 Quite Low
Lung Cancer 2 38.96 Quite Low
Death 8 5.00 Very Low Very Low Very Low
Chorioamnionitis 6 5.00 Very Low Very Low Very Low
Sepsis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that hyperoxia and dexamethasone, both of which impair alveolarization, strongly reduced lung MMP16 gene expression in newborn rats.
Negative_regulation (reduced) of Gene_expression (expression) of MMP16 gene in lung associated with hyperoxia and dexamethasone
1) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.36 Pain Relevance 0.05
In addition, MMP16 gene expression was high during normal newborn rat lung alveolarization, and was markedly reduced by insults that arrested alveolarization.
Negative_regulation (reduced) of Gene_expression (expression) of MMP16 gene in lung
2) Confidence 0.55 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527515 Disease Relevance 0.94 Pain Relevance 0.06

General Comments

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