INT244807

Context Info Confidence 0.26 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0 Pain Relevance 0

cell differentiation (Lbx1) nucleus (Lbx1) DNA binding (Lbx1)

Anatomy Link Frequency nodes 1 Lbx1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 8 5.00 substantia gelatinosa 8 5.00 Dorsal horn neuron 4 5.00 Central nervous system 4 5.00 Pain 4 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 24 5.00 Apoptosis 8 5.00 Pain 4 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on these considerations one would predict that Lbx1 regulates between 25 and 141 SSTF genes in each D–V cell type.

Regulation (regulates) of Lbx1

1) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

There is also a clear interlocking of the two data sets because 30 of the known nodes are Lbx1 targets and because virtually all of the known Lbx1 interactions were recapitulated in the ANCEA dataset.

Regulation (targets) of Lbx1 in nodes

2) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

The frequency of Lbx1 targets at the top of the list is higher than at the bottom.

Regulation (targets) of Lbx1

3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

Lists of SSTF genes that are targets of Lbx1 in green cells (Tables 1, 2) were established by applying similar algorithms as in the permutation fold-scanning analyses above.

Regulation (targets) of Lbx1

4) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.