INT244922

Context Info Confidence 0.39 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.10 Pain Relevance 0.06

cytosol (SPTBN1) nucleolus (SPTBN1) plasma membrane (SPTBN1) nucleus (SPTBN1) cytoplasm (SPTBN1)

Anatomy Link Frequency lenses 2 SPTBN1 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 2 62.04 Kinase C 6 52.64 Dopamine 4 5.00 Central nervous system 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Hyperopia 18 53.76 Disorder Of Lipid Metabolism 2 50.28 Myopia 44 50.00 Sarcoma 2 5.00 Overdose 2 5.00 Adhesions 2 5.00 Osteogenic Sarcomas 2 5.00 Refractive Errors 2 5.00 Thymoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The first cluster includes genes that showed changes in the same directions, no matter whether positive or negative lenses were used: “image sharpness detection” (ATE1, ELF1, GRB2, SHQ1, SPTBN1, and pp-URP).

Transcription (detection) of SPTBN1 in lenses

1) Confidence 0.39 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0 Pain Relevance 0

Since SPTBN1 mRNA expression was generally upregulated in both the positive- and the negative lens-treated group, we propose a more general role of this protein in retinal processing.

Transcription (expression) of SPTBN1 in lens

2) Confidence 0.30 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0.10 Pain Relevance 0.06

General Comments

This test has worked.