INT245587

Context Info Confidence 0.27 First Reported 2008 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 13 Total Number 15 Disease Relevance 4.68 Pain Relevance 5.72

lyase activity (Car1) Golgi apparatus (Car1) cytoplasm (Car1)

Anatomy Link Frequency hippocampus 3 astrocyte 2 pyramidal cells 1 molecular layer 1 spikes 1 Car1 (Mus musculus)

Pain Link Frequency Relevance Heat nMDA receptor 225 100.00 ketamine 93 100.00 Hippocampus 254 99.96 Somatosensory cortex 18 99.88 Pyramidal cell 186 99.76 ischemia 57 99.32 long-term potentiation 62 99.12 anesthesia 77 94.28 Limbic system 5 92.20 amygdala 15 92.08

Disease Link Frequency Relevance Heat Hypersensitivity 12 99.88 Transient Ischemic Attack 13 99.32 Neurodegenerative Disease 391 99.14 Anxiety Disorder 72 98.56 Death 63 97.76 Hypertrophy 12 94.28 Gliosis 69 91.68 Pain 29 90.92 INFLAMMATION 287 90.40 Neuropathic Pain 3 90.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The difference in the neural wiring pattern such as the abundance of recurrent networks may underlie the different effects of NMDA receptor ablation in the hippocampal CA1 and CA3 regions on network activity.

Regulation (effects) of CA1 in neural associated with nmda receptor

1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0.06 Pain Relevance 0.60

Recording from the cortex and hippocampal CA1 region, spikes reversed their polarity in the CA1 stratum oriens.

Regulation (polarity) of CA1 in spikes

2) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615205 Disease Relevance 0 Pain Relevance 0.23

In line of this criterion, we have indeed observed that these CA1 dynamics patterns reappeared at the time of both contextual and traced fear retention tests.

Regulation (reappeared) of CA1 associated with anxiety disorder

3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788416 Disease Relevance 0.19 Pain Relevance 0.06

No staining was detected in the lacunosum-molecular layer in CA1, CA2 and CA3 (Figures 9b, 9c and 9d).

Regulation (molecular layer) of CA1 in molecular layer

4) Confidence 0.19 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2531118 Disease Relevance 0.22 Pain Relevance 0.19

However, dissociations have also been shown; for example, in a fear conditioning task, it was shown, using oligonucleotide antisense, that regulation of the transcription factor, Zif268/Egr1 in CA1 of the hippocampus was not necessary for consolidating fear memory, but was necessary for reconsolidation of the active memory (Lee et al., 2004).

Regulation (regulation) of CA1 in hippocampus associated with anxiety disorder and hippocampus

5) Confidence 0.18 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2992451 Disease Relevance 0.27 Pain Relevance 0.09

In contrast to the small, but significant, changes in average firing rates of putative pyramidal cells, the major effect of ketamine on CA1 was the dramatic change in ensemble dynamic patterns.

Regulation (effect) of CA1 in pyramidal cells associated with ketamine and pyramidal cell

6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999569 Disease Relevance 0.11 Pain Relevance 0.85

S1), subsequent neurogenesis actually partly restored the total neuron populations in the CA3 and CA1 regions.

Regulation (populations) of CA1 in neuron associated with neurodegenerative disease

7) Confidence 0.15 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.54 Pain Relevance 0.04

In the hippocampal CA1 region where most of LTP studies have been reported, LTP can be induced and reliable detected, even with field recording electrodes [7,8].

Regulation (hippocampal) of CA1 associated with long-term potentiation

8) Confidence 0.14 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.74 Pain Relevance 1.07

We then wondered whether these changes were specific to the SSC, and therefore evaluated the effects of these three anesthetics on the development of dendritic protrusions in another cortical region, area CA1 of the hippocampus, where cells also express YFP.

Spec (whether) Regulation (effects) of CA1 in hippocampus associated with somatosensory cortex and hippocampus

9) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0.22 Pain Relevance 0.70

Similarly to observations made in the SSC, the effects of the three anesthetics on CA1 dendritic spines were dependent on the age of the animals (Fig. 4b), thus reproducing the changes observed in the SSC.

Regulation (effects) of CA1 in spines associated with somatosensory cortex

10) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738943 Disease Relevance 0.27 Pain Relevance 0.73

The number of Nissl-stained neuronal profile in areas CA3, CA1, the dentate hilus, and the dentate gyrus were counted in both the right and left hippocampus in horizontal sections for each animal by using four to five Nissl-stained sections that were ?

Regulation (left) of CA1 in hilus associated with hippocampus

11) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001489 Disease Relevance 0 Pain Relevance 0.14

Infusion of activin A itself had no additional effect on astrocyte proliferation in the hippocampal DG, CA3, CA1, and pPV regions after KA injection (Fig. 3K).

Neg (no) Regulation (effect) of CA1 in astrocyte

12) Confidence 0.08 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.34 Pain Relevance 0.18

To determine whether activin A had a role in this process, we first assessed whether activin A regulated the number of proliferating astrocytes in the DG, CA3, CA1, and pPV regions [7, 24].

Spec (whether) Regulation (regulated) of CA1 in astrocytes

13) Confidence 0.08 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733378 Disease Relevance 0.48 Pain Relevance 0.13

Mice were anaesthetized with tribromoethanol (200 mg/kg) and stereotaxic surgery was performed to implant a 3 mm cannula at -1.5 mm posterior and -2.0 mm lateral from bregma and 2.5 mm deep by the insertion of 2 spacers (0.25 mm each) to target the CA1 of the right hippocampus in each 2-month old C57BL/6 female mice [24].

Regulation (target) of CA1 in hippocampus associated with hippocampus

14) Confidence 0.06 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2612658 Disease Relevance 0.08 Pain Relevance 0.29

The changes in the CA1, CA2/3, and dentate gyrus were termed delayed neuronal death, reactive change, and ischemic cell change, respectively.

Regulation (changes) of CA1 in neuronal associated with death

15) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998780 Disease Relevance 1.15 Pain Relevance 0.42

General Comments

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