INT245747

Context Info Confidence 0.42 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.05 Pain Relevance 0.06

extracellular region (COL9A3)

COL9A3 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 1 55.96 Osteoarthritis 1 54.76 backache 4 5.00 Inflammation 3 5.00 Pain 2 5.00 COX2 1 5.00 cytokine 1 5.00 imagery 1 5.00 Sciatica 1 5.00

Disease Link Frequency Relevance Heat Intervertebral Disk Degeneration 39 99.90 Scheuermann's Disease 1 93.80 Obesity 2 87.36 Disease 33 66.04 Chondrodysplasia 1 57.16 Rheumatoid Arthritis 1 55.96 Osteoarthritis 1 54.76 Low Back Pain 4 5.00 INFLAMMATION 3 5.00 Nicotine Addiction 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Solovieva et al 22 had further researched the relation of gene-environment interaction, and found that incidence rate of lumbar disc degeneration was increased for interactions of the mutation of COL9A3 gene with persistent load on disc.

Positive_regulation (increased) of COL9A3 gene Binding (interactions) of associated with intervertebral disk degeneration

1) Confidence 0.42 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 1.05 Pain Relevance 0.06

General Comments

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