INT245765

Context Info Confidence 0.31 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.87 Pain Relevance 0

signal transduction (SOX9) nucleolus (SOX9) nucleus (SOX9) extracellular matrix organization (SOX9) protein complex assembly (SOX9) protein complex (SOX9)

Anatomy Link Frequency intervertebral disc 2 SOX9 (Homo sapiens)

Pain Link Frequency Relevance Heat backache 8 5.00 Inflammation 6 5.00 Pain 4 5.00 COX2 2 5.00 cytokine 2 5.00 rheumatoid arthritis 2 5.00 Osteoarthritis 2 5.00 imagery 2 5.00 Sciatica 2 5.00

Disease Link Frequency Relevance Heat Disease 66 100.00 Intervertebral Disk Degeneration 78 99.16 Aging 2 92.56 Spinal Osteophytosis 4 33.28 Obesity 4 23.08 Scheuermann's Disease 2 5.56 Low Back Pain 8 5.00 INFLAMMATION 6 5.00 Nicotine Addiction 6 5.00 Pain 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Mutation and polymorphism of Sox9 gene and association with intervertebral disc degeneration remain to be studied. 4.5 Vitamin D receptor

Sox9 Binding (association) of in intervertebral disc associated with intervertebral disk degeneration

1) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.47 Pain Relevance 0

To date, there are no known associations of polymorphisms in collagen type IV and/or collagen type X genes, with intervertebral disc disease. 4.4 Sox9

Sox9 Binding (intervertebral) of in intervertebral disc associated with disease

2) Confidence 0.31 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.40 Pain Relevance 0

General Comments

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