INT245946

Context Info Confidence 0.44 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.24

mitochondrion (MRPS7) structural constituent of ribosome (MRPS7) ribosome (MRPS7) RNA binding (MRPS7) intracellular (MRPS7) translation (MRPS7)

Anatomy Link Frequency external 2 MRPS7 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 18 100.00 Pain 3 62.80 Nicotine 16 55.92 Glutamate 28 5.00 alcohol 3 5.00 Acupuncture 3 5.00 Potency 3 5.00 qutenza 2 5.00 antagonist 2 5.00 medulla 1 5.00

Disease Link Frequency Relevance Heat Pain 3 62.80 Targeted Disruption 14 5.00 Aging 2 5.00 Overdose 1 5.00 Taste Disorders 1 5.00 Body Weight 1 5.00 Blister 1 5.00 Peripheral Arterial Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that H+ binding to an external site on the TRPV1t channel protein modulates the affinity of TRPV1t agonists, including that of MRPs, to their respective intracellular binding sites on the channel protein.

Regulation (modulates) of Regulation (affinity) of MRPs in external associated with agonist

1) Confidence 0.44 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.06 Pain Relevance 0.24

General Comments

This test has worked.