INT246013

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.29
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nr4a2) DNA binding (Nr4a2) response to stress (Nr4a2)
cytoplasm (Nr4a2)
Anatomy Link Frequency
neurons 2
Nr4a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 90.08 High High
interneuron 2 66.16 Quite High
GABAergic 4 62.60 Quite High
Hippocampus 29 44.24 Quite Low
imagery 4 40.40 Quite Low
Somatosensory cortex 3 15.64 Low Low
anesthesia 9 5.00 Very Low Very Low Very Low
cerebral cortex 7 5.00 Very Low Very Low Very Low
primary somatosensory cortex 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 18 97.96 Very High Very High Very High
Urological Neuroanatomy 5 86.32 High High
Disease 2 81.68 Quite High
Syndrome 2 73.28 Quite High
Intrauterine Growth Retardation 2 66.92 Quite High
Congenital Anomalies 6 42.32 Quite Low
Thyroid Disease 12 21.24 Low Low
Body Weight 15 5.00 Very Low Very Low Very Low
Birth Weight 12 5.00 Very Low Very Low Very Low
Hypersensitivity 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The distribution pattern shown in Fig. 6A suggests that the RORbeta mRNA expression level is high in the sensory areas, whereas the ER81 and Nurr1 mRNA expression levels are generally high in the areas with low RORbeta mRNA expression level.
Transcription (levels) of Nurr1 mRNA
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
On the other hand, RORbeta and Nurr1 mRNAs were not coexpressed in the same neurons even in the areas with extensive intermingling (Fig. 3D–3F).
Neg (not) Transcription (coexpressed) of Nurr1 in neurons
2) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Similarly, ER81 and Nurr1 mRNAs were not expressed within the same neurons (Fig. 3G–3I).
Neg (not) Transcription (expressed) of Nurr1 in neurons
3) Confidence 0.36 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533703 Disease Relevance 0 Pain Relevance 0
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Transcription (transcription) of Nurr1 associated with schizophrenia
4) Confidence 0.23 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.64 Pain Relevance 0.14
Furthermore, altered expression of other genes such as nuclear orphan transcription factor Nur-related receptor 1 (Nurr1) (Xing et al. 2006) or Neuregulin 1 is altered in schizophrenia (Harrison and Law 2006; Addington et al. 2007).
Transcription (transcription) of Nur-related receptor 1 associated with schizophrenia
5) Confidence 0.23 Published 2010 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2871377 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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