INT246088

Context Info Confidence 0.37 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.01 Pain Relevance 1.00

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT) plasma membrane (COMT) cytoplasm (COMT)

COMT (Homo sapiens)

Pain Link Frequency Relevance Heat Catechol-O-methyltransferase 111 100.00 agonist 57 100.00 Dopamine 22 100.00 monoamine 1 99.82 IPN 6 80.52 Pain 22 72.76 allodynia 2 50.48 Hyperalgesia 1 48.76 Inflammation 8 11.44 Inflammatory response 2 7.60

Disease Link Frequency Relevance Heat Psychosis 7 90.64 Disease 105 84.48 Confusion 1 82.68 Inflammatory Pain 6 80.52 Hallucination 5 79.96 Pain 22 72.76 Nociception 3 67.88 Diabetes Mellitus 1 66.28 Pressure And Volume Under Development 3 65.88 Cardiovascular Disease 1 65.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Using quantitative real-time RT-PCR analysis, we further demonstrated a down-regulation of MB-COMT mRNA at 0.5 h and 30 h following TNF?

Negative_regulation (down) of Negative_regulation (regulation) of MB-COMT mRNA associated with catechol-o-methyltransferase

1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.50 Pain Relevance 0.75

Borek and colleagues (2007) suggested eliminating anticholinergics first, followed by amantadine, monoamine oxidase inhibitors, dopamine agonists, COMT inhibitors, then reducing the amount of levodopa.

Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of COMT associated with dopamine, agonist and monoamine

2) Confidence 0.23 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.51 Pain Relevance 0.24

General Comments

This test has worked.