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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.01
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (COMT) mitochondrion (COMT) small molecule metabolic process (COMT)
plasma membrane (COMT) cytoplasm (COMT)
COMT (Homo sapiens)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 111 100.00 Very High Very High Very High
agonist 57 100.00 Very High Very High Very High
Dopamine 22 100.00 Very High Very High Very High
monoamine 1 99.82 Very High Very High Very High
IPN 6 80.52 Quite High
Pain 22 72.76 Quite High
allodynia 2 50.48 Quite High
Hyperalgesia 1 48.76 Quite Low
Inflammation 8 11.44 Low Low
Inflammatory response 2 7.60 Low Low
Disease Link Frequency Relevance Heat
Psychosis 7 90.64 High High
Disease 105 84.48 Quite High
Confusion 1 82.68 Quite High
Inflammatory Pain 6 80.52 Quite High
Hallucination 5 79.96 Quite High
Pain 22 72.76 Quite High
Nociception 3 67.88 Quite High
Diabetes Mellitus 1 66.28 Quite High
Pressure And Volume Under Development 3 65.88 Quite High
Cardiovascular Disease 1 65.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using quantitative real-time RT-PCR analysis, we further demonstrated a down-regulation of MB-COMT mRNA at 0.5 h and 30 h following TNF?
Negative_regulation (down) of Negative_regulation (regulation) of MB-COMT mRNA associated with catechol-o-methyltransferase
1) Confidence 0.37 Published 2009 Journal Mol Pain Section Body Doc Link PMC2662804 Disease Relevance 0.50 Pain Relevance 0.75
Borek and colleagues (2007) suggested eliminating anticholinergics first, followed by amantadine, monoamine oxidase inhibitors, dopamine agonists, COMT inhibitors, then reducing the amount of levodopa.
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of COMT associated with dopamine, agonist and monoamine
2) Confidence 0.23 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536542 Disease Relevance 1.51 Pain Relevance 0.24

General Comments

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