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Context Info
Confidence 0.39
First Reported 1981
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 6.98
Pain Relevance 4.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
sciatic nerve 8
hypothalamus 3
fat 2
neurons 2
spinal cord dorsal horn 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 16 100.00 Very High Very High Very High
Sciatic nerve 9 100.00 Very High Very High Very High
tetrodotoxin 1 99.84 Very High Very High Very High
Spinal cord 3 99.64 Very High Very High Very High
Clonidine 10 99.20 Very High Very High Very High
sodium channel 2 99.20 Very High Very High Very High
Dorsal horn 1 99.16 Very High Very High Very High
agonist 2 98.86 Very High Very High Very High
Calcium channel 1 97.60 Very High Very High Very High
Painful diabetic neuropathy 1 94.32 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 40 99.52 Very High Very High Very High
Volume Depletion And Dehydration 1 98.20 Very High Very High Very High
Diabetic Neuropathy 1 94.32 High High
Nervous System Injury 1 90.96 High High
Hyperalgesia 4 89.32 High High
Obesity 26 84.48 Quite High
Aging 38 83.64 Quite High
Pain 2 82.12 Quite High
Nociception 25 79.68 Quite High
Neuropathic Pain 16 78.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Negative_regulation (decreased) of Gene_expression (expressions) of IGF-IR in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
1) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.40 Pain Relevance 0.48
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of Gene_expression (expressions) of IGF-IR in sciatic nerve associated with nerve growth factor and sciatic nerve
2) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of Gene_expression (expressions) of insulin receptor in sciatic nerve associated with nerve growth factor and sciatic nerve
3) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.37 Pain Relevance 0.46
Insulin receptor and IGF-I receptor (IGF-IR) expressions in DRGs and NGF content in sciatic nerve were significantly decreased in 7-month diabetic rats (P < 0.01, 0.05, and 0.005, respectively).
Negative_regulation (decreased) of Gene_expression (expressions) of Insulin receptor in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
4) Confidence 0.39 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.42 Pain Relevance 0.48
Chronic treatment with the alpha-adrenergic agonist, clonidine (CLON), increased, whereas treatment with EB decreased, IR-BE levels in the AP, NIL and hypothalamus.
Negative_regulation (decreased) of Gene_expression (levels) of IR-BE in hypothalamus associated with agonist and clonidine
5) Confidence 0.33 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.64
The effect of veratridine on IR-SRIF and protein synthesis was reversed by tetrodotoxin, a sodium channel blocker, or verapamil, a calcium channel blocker.
Negative_regulation (reversed) of Gene_expression (synthesis) of IR-SRIF associated with tetrodotoxin, calcium channel and sodium channel
6) Confidence 0.21 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.39
Dehydration of rats by 5 days enforced inhibition of a 2% solution of NaCl resulted in a significant decrease in the levels of ir-DYN, ir-1-ENK and ir-VP, but not in those of ir-beta-END in the neurointermediate lobe of the pituitary.
Neg (not) Negative_regulation (decrease) of Gene_expression (levels) of ir-DYN in lobe associated with volume depletion and dehydration
7) Confidence 0.17 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6275285 Disease Relevance 0.10 Pain Relevance 0.28
Expression of insulin receptor, IGF-1R, TrkA and C was decreased in BB/Wor rats, whereas BBZDR/Wor rats showed milder or no deficits.
Negative_regulation (decreased) of Gene_expression (Expression) of insulin receptor
8) Confidence 0.16 Published 2005 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 15747389 Disease Relevance 0.06 Pain Relevance 0
There is a significant down-regulation in the expression of IGF-I and IGF-IR in the small DRG neurons of STZ rats by 59% and 71%, respectively.
Negative_regulation (down-regulation) of Gene_expression (expression) of IGF-IR in neurons
9) Confidence 0.13 Published 2002 Journal Neuroreport Section Abstract Doc Link 12352620 Disease Relevance 0.26 Pain Relevance 0.22
Chronic treatment with the alpha-adrenergic agonist, clonidine (CLON), increased, whereas treatment with EB decreased, IR-BE levels in the AP, NIL and hypothalamus.
Negative_regulation (decreased) of in NIL Gene_expression (levels) of IR-BE in hypothalamus associated with agonist and clonidine
10) Confidence 0.11 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.64
RESULTS: In addition to decreased insulin secretory capacity, pancreatogenic (or apancreatic) diabetes is characterized by decreased or absent glucagon and pancreatic polypeptide (PP) secretion, a loss of hepatic insulin receptor (IR) expression/availability, and an impairment in hepatic IR function (phosphorylation and endocytosis).
Negative_regulation (loss) of Gene_expression (expression/availability) of insulin
11) Confidence 0.05 Published 2007 Journal Pancreas Section Body Doc Link 17575539 Disease Relevance 0 Pain Relevance 0
Paradoxically, these increases in Akt phosphorylation were associated with diminished mammalian target of rapamycin (mTOR) phosphorylation, along with decreased levels of insulin receptor beta (IR-?)
Negative_regulation (decreased) of Gene_expression (levels) of insulin receptor beta
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.29 Pain Relevance 0.16
Similarly, the antisense oligodeoxynucleotide virtually abolished formalin-induced expression of c-Fos-like immunoreactivity (Fos-IR) in the spinal cord dorsal horn ipsilateral to injection.
Negative_regulation (abolished) of Gene_expression (expression) of Fos-IR in spinal cord dorsal horn associated with dorsal horn and spinal cord
13) Confidence 0.03 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15388298 Disease Relevance 0.44 Pain Relevance 0.40
Fasting blood glucose, insulin, C-peptide, and HOMA-IR levels were also significantly reduced in the corn gluten hydrolyzates groups, regardless of fat level (Table 7).
Negative_regulation (reduced) of Gene_expression (levels) of HOMA-IR in fat
14) Confidence 0.02 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2867220 Disease Relevance 0.27 Pain Relevance 0

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