INT24621

Context Info Confidence 0.42 First Reported 1985 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 9 Total Number 9 Disease Relevance 2.68 Pain Relevance 2.18

cytosol (Insr) endosome (Insr) plasma membrane (Insr) nucleus (Insr)

Anatomy Link Frequency pituitary 8 plasma 2 hypothalamus 2 TMJ 2 brain 2 Insr (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 4 100.00 Dynorphin 4 100.00 tetrodotoxin 1 99.32 sodium channel 2 98.68 Calcium channel 1 97.08 Snapping jaw 3 95.64 cva 4 93.28 antagonist 1 88.32 Dopamine 1 87.88 Somatostatin 4 78.40

Disease Link Frequency Relevance Heat Hemorrhagic Shock 8 100.00 Sprains And Strains 8 99.98 Temporomandibular Joint Syndrome 3 95.64 Diabetes Mellitus 13 93.68 Hemorrhage 8 93.28 Body Weight 3 92.72 Insulin Resistance 10 88.08 INFLAMMATION 1 86.84 Obesity 85 67.68 Stress 19 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.

Regulation (effect) of Gene_expression (distribution) of LE-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock

1) Confidence 0.42 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.27 Pain Relevance 0.27

The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.

Regulation (effect) of Gene_expression (distribution) of A-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock

2) Confidence 0.37 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.26 Pain Relevance 0.27

The effect of EB on IR-BE levels in the AP and NIL was reversed by administration of HALO, while EB and HALO appeared to act independently on the hypothalamus.

Regulation (effect) of Gene_expression (levels) of IR-BE in hypothalamus

3) Confidence 0.21 Published 1986 Journal Peptides Section Abstract Doc Link 2948165 Disease Relevance 0 Pain Relevance 0.38

IR-BE levels in the NIL were unchanged.

Neg (unchanged) Regulation (unchanged) of Gene_expression (levels) of IR-BE in NIL

4) Confidence 0.19 Published 1985 Journal Diabetes Section Abstract Doc Link 2931314 Disease Relevance 0.42 Pain Relevance 0.06

The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.

Regulation (effect) of in brain Gene_expression (distribution) of LE-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock

5) Confidence 0.14 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.27 Pain Relevance 0.27

The effect of veratridine on IR-SRIF and protein synthesis was reversed by tetrodotoxin, a sodium channel blocker, or verapamil, a calcium channel blocker.

Regulation (effect) of Gene_expression (synthesis) of IR-SRIF associated with tetrodotoxin, calcium channel and sodium channel

6) Confidence 0.13 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.39

The effect of hemorrhagic shock (40% of blood vol) on the distribution of immunoreactive dynorphin A (Dyn A-IR), [Arg8]vasopressin (AVP-IR), and [Leu5]enkephalin (LE-IR) in the pituitary and brain nuclei was studied in the conscious rat.

Regulation (effect) of in brain Gene_expression (distribution) of A-IR in pituitary associated with dynorphin, enkephalin and hemorrhagic shock

7) Confidence 0.13 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.26 Pain Relevance 0.27

FRD rats, however, had significantly higher plasma triglyceride, fructosamine and insulin levels (1.61 ± 0.14 vs. 1.13 ± 0.08 mmol/L, P < 0.02; 162.6 ± 3.3 vs. 146.2 ± 5.6 ?

Regulation (had) of Gene_expression (levels) of insulin in plasma

8) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2974659 Disease Relevance 0.37 Pain Relevance 0

The objective of this in vitro study was to determine if continuous biophysical strain regulates the gene expression of IGF1, IGF2, IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), and IGF-binding proteins (IGFBP) 3 and 5 in cells from the fibrocartilaginous disc of the temporomandibular joint (TMJ).

Regulation (regulates) of Gene_expression (expression) of insulin receptor in TMJ associated with snapping jaw and sprains and strains

9) Confidence 0.12 Published 2007 Journal Ann. Anat. Section Abstract Doc Link 17695985 Disease Relevance 0.82 Pain Relevance 0.28

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