INT246311

From wiki-pain
Revision as of 22:17, 24 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 1.15
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
cleavage 5
neurons 1
nerve 1
vesicles 1
synapses 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Botox 22 99.98 Very High Very High Very High
Spinal cord 184 99.52 Very High Very High Very High
Calcium channel 19 90.72 High High
headache 1 79.36 Quite High
Neurotransmitter 27 68.16 Quite High
antagonist 14 65.40 Quite High
tetrodotoxin 60 58.52 Quite High
GABAergic 45 58.00 Quite High
Action potential 64 50.00 Quite Low
Potency 1 42.40 Quite Low
Disease Link Frequency Relevance Heat
Clostridium Infection 1 99.32 Very High Very High Very High
Toxicity 4 90.80 High High
Paralysis 32 85.68 High High
Dysphagia 80 84.92 Quite High
Pressure Volume 2 Under Development 1 80.44 Quite High
Dizziness 1 79.80 Quite High
Headache 1 79.36 Quite High
Wrinkles 3 77.68 Quite High
Cerebral Palsy 3 75.72 Quite High
Dystonia 6 74.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased intracellular calcium ([Ca2+]i) would be expected to increase the frequency and amplitude of mPSCs [for review, see ref. [9]], yet previous evidence has shown that genetic deletion or BoNT cleavage of SNAP-25 can result in decreased mPSC frequency [10-13].
Protein_catabolism (cleavage) of SNAP-25 in cleavage
1) Confidence 0.66 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.17
Moreover, competition of HCR/T with BoNT/E in hippocampal neurons reduced the extent of cleavage of SNAP-25 (Figure 4C).
Protein_catabolism (cleavage) of SNAP-25 in cleavage
2) Confidence 0.32 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.11 Pain Relevance 0
Since it is known that cleavage of SNAP-25 by BoNT/A influences the dynamics of quantal release at other synapses (Sakaba et al. 2005), we attempted to define these changes in more detail.
Protein_catabolism (cleavage) of SNAP-25 in synapses
3) Confidence 0.29 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0
These may well be related to recovery from the effects of the cleavage of SNAP-25 (Sakaba et al. 2005).
Protein_catabolism (cleavage) of SNAP-25 in cleavage
4) Confidence 0.29 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0.05
It then specifically cleaves SNAP-25, an essential protein in exocytosis, thus preventing the ‘quantal’ release of ACh in response to nerve impulses (Schiavo et al. 2000).
Protein_catabolism (cleaves) of SNAP-25 in nerve
5) Confidence 0.29 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.23 Pain Relevance 0
Similar results were observed using hippocampal neurons that had been pretreated with BoNT/E, which also cleaves SNAP-25 (Figure 3C).
Protein_catabolism (cleaves) of SNAP-25 in neurons
6) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.09 Pain Relevance 0.04
Hence, we first pre-treated spinal cord neurons with BoNT/A to cleave SNAP-25 and inhibit exocytosis [1], and then we subsequently assayed for entry of TeNT by monitoring cleavage of syb II.
Protein_catabolism (cleave) of SNAP-25 in cleavage associated with spinal cord
7) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.06 Pain Relevance 0.13
As BoNT/A and BoNT/E cleave SNAP-25 instead of syb II, we were able to inhibit exocytosis in neurons while still monitor the entry of TeNT through cleavage of syb II.
Protein_catabolism (cleave) of SNAP-25 in cleavage
8) Confidence 0.24 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.16
Botox cleaves SNAP-25, a cytoplasmic protein involved in the fusion of acetylcholine containing presymptomatic vesicles with the neuronal plasma membrane.
Protein_catabolism (cleaves) of SNAP-25 in vesicles associated with botox
9) Confidence 0.17 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2912115 Disease Relevance 0.66 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox