INT246365

Context Info Confidence 0.00 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.34 Pain Relevance 0.15

cytosol (MAP2K6) nucleoplasm (MAP2K6) signal transduction (MAP2K6) cytoskeleton (MAP2K6) nucleus (MAP2K6) response to stress (MAP2K6)

CALM1 (Homo sapiens) MAP2K6 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 9 100.00 Inflammatory mediators 2 5.00 adenocard 2 5.00 Inflammation 2 5.00 chemokine 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Bacillus Anthracis Infection 22 95.92 Infection 10 70.32 Communicable Diseases 1 61.32 Yersinia Infection 18 51.80 Apoptosis 6 34.44 Hypoxia 2 16.52 Bordatella Infection 1 9.52 Venezuelan Equine Encephalomyelitis 9 5.00 Dengue 5 5.00 Death 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Comparisons of in vitro/in vivo results showed similarities in genes that code for lymphoid receptors/signaling pathways that, when taken as a group, showed a pattern specific for B. anthracis and include a G-protein Transducin beta subunit (GNB1), cAMP related genes, Calmodulin regulated genes, cytokines and MAPKK (mitogen activated protein kinase kinase), some of which had previously been reported in response to anthrax exposures [40].

Calmodulin Regulation (regulated) of MAPKK associated with bacillus anthracis infection and cytokine

1) Confidence 0.00 Published 2008 Journal BMC Infect Dis Section Body Doc Link PMC2542375 Disease Relevance 0.34 Pain Relevance 0.15

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