INT24643

Context Info Confidence 0.73 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 30 Total Number 30 Disease Relevance 26.83 Pain Relevance 1.90

Anatomy Link Frequency blood 3 plasma 3 erythrocyte 2 tubes 1 leg 1 Hdlcl1 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 18 99.72 Angina 24 98.04 depression 1 90.60 tolerance 15 86.32 Restless leg syndrome 3 86.24 cva 7 78.64 ischemia 11 75.00 alcohol 19 74.52 anesthesia 1 74.48 behavioral therapy 14 63.60

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 1015 100.00 Hyperlipidemia 46 100.00 Dyslipidemia / Combined Dyslipidemia 198 99.96 Pain 15 99.72 Coronary Artery Disease 174 99.54 Obesity 62 99.38 Diabetes Mellitus 403 98.86 Body Weight 91 98.80 Coronary Heart Disease 73 98.76 Cv General 3 Under Development 26 98.04

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Plasma levels of cholesterol, triglycerides, and LDL- and HDL-cholesterol did not show any significant alterations.

Gene_expression (levels) of HDL-cholesterol in Plasma associated with disorder of lipid metabolism

1) Confidence 0.73 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468868 Disease Relevance 0.59 Pain Relevance 0.29

Mean HDL-cholesterol levels were lower for those with GXT-induced leg pain in all three sex-hormone usage groups (42.0 vs 46.9, p less than .001; 53.9 vs 59.4, p less than .001; 65.3 vs 67.2, p = NS) and mean low-density lipoprotein cholesterol levels were higher in those with leg pain on GXT in two of three groups (146.4 vs 146.2, p = NS; 155.7 vs 144.6, p less than .01; 144.4 vs 133.5, p less than .05).

Gene_expression (levels) of HDL-cholesterol in leg associated with pain and disorder of lipid metabolism

2) Confidence 0.64 Published 1986 Journal Circulation Section Abstract Doc Link 3940676 Disease Relevance 1.12 Pain Relevance 0.55

The effect of bark powder of Terminalia arjuna, an indigenous drug, on anginal frequency, blood pressure, body mass index, blood sugar, cholesterol and HDL-cholesterol was studied in 15 stable (Group A) and 5 unstable (Group B) angina patients before and 3 months after T. arjuna therapy.

Gene_expression (studied) of HDL-cholesterol in blood associated with angina, obesity and disorder of lipid metabolism

3) Confidence 0.64 Published 1994 Journal J Assoc Physicians India Section Abstract Doc Link 7741874 Disease Relevance 0.62 Pain Relevance 0.25

Hyperlipidemia is frequently found in these patients and the most common lipid derangements are low levels of HDL-cholesterol and hypertriglyceridemia.

Gene_expression (levels) of HDL-cholesterol associated with hyperlipidemia and disorder of lipid metabolism

4) Confidence 0.57 Published 2001 Journal Lakartidningen Section Abstract Doc Link 11586809 Disease Relevance 1.07 Pain Relevance 0.16

Correcting low HDL-cholesterol improves cardiovascular outcomes

Gene_expression (Correcting) of HDL-cholesterol associated with disorder of lipid metabolism

5) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.09 Pain Relevance 0

Since HDL-cholesterol is an important cardiovascular risk factor, addressing both hypercholesterolemia and low HDL-cholesterol is a rational clinical strategy for patients with these lipid abnormalities.

Gene_expression (addressing) of HDL-cholesterol associated with congenital anomalies, hyperlipidemia and disorder of lipid metabolism

6) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.14 Pain Relevance 0

High prevalence of low HDL-cholesterol despite lipid-modifying intervention

Gene_expression (prevalence) of HDL-cholesterol associated with disorder of lipid metabolism

7) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.25 Pain Relevance 0

However, a re-analysis of these data in a manner consistent with the US studies described above (in terms of covariates used) revealed a consistent inverse relationship between HDL-cholesterol levels and coronary risk (Gordon et al 1989).

Gene_expression (levels) of HDL-cholesterol associated with disorder of lipid metabolism

8) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.06 Pain Relevance 0

A further analysis in 3866 type 2 diabetes patients within the survey population revealed a higher prevalence of low HDL-cholesterol in this population (45%) (Bruckert et al 2007).

Gene_expression (prevalence) of HDL-cholesterol associated with diabetes mellitus and disorder of lipid metabolism

9) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.18 Pain Relevance 0

Simultaneous correction of low HDL-cholesterol and high total-cholesterol and LDL-cholesterol may provide reductions in cardiovascular morbidity and mortality beyond those possible with statins alone.

Gene_expression (correction) of HDL-cholesterol associated with disorder of lipid metabolism

10) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2291331 Disease Relevance 0.33 Pain Relevance 0

Since HDL-cholesterol is an important cardiovascular risk factor, addressing both hypercholesterolemia and low HDL-cholesterol is a rational clinical strategy for patients with these lipid abnormalities.

Gene_expression (addressing) of HDL-cholesterol associated with congenital anomalies, hyperlipidemia and disorder of lipid metabolism

11) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.15 Pain Relevance 0

Moreover, a markedly higher prevalence of low HDL-cholesterol was observed in patients with coronary heart disease (45.2%) relative to those without (16.1%) (Assmann et al 1996).

Gene_expression (prevalence) of HDL-cholesterol in heart associated with coronary heart disease and disorder of lipid metabolism

12) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.15 Pain Relevance 0

Many patients will therefore require combination therapy with Niaspan® plus a statin to correct concomitant disturbances of LDL-cholesterol and HDL-cholesterol metabolism.

Gene_expression (metabolism) of HDL-cholesterol associated with disorder of lipid metabolism

13) Confidence 0.42 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.45 Pain Relevance 0

Serum low-density lipoprotein (LDL)-cholesterol level was calculated from serum TC, HDL-cholesterol and TG levels (Friedewald et al., 1972).

Gene_expression (levels) of HDL-cholesterol associated with disorder of lipid metabolism

14) Confidence 0.17 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 0.54 Pain Relevance 0

Several body weight loss interventions have reported improvements on serum TC, HDL-cholesterol and LDL-cholesterol levels (Lee et al., 2005) and improvements in TC and LDL-cholesterol levels (Seo, 2005), besides improvements in HDL-cholesterol levels (Lee et al., 2007) with aerobic exercise in middle-aged women.

Gene_expression (levels) of HDL-cholesterol in body associated with body weight and disorder of lipid metabolism

15) Confidence 0.17 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 1.18 Pain Relevance 0.03

Conventional risk factors for CHD such as dyslipidemia (HDL-cholesterol levels <45 mg/dl, triglyceride levels >150 mg/dl and LDL-cholesterol levels>130 mg/dl), hypertension (blood pressure > 130/80 or prior therapy), diabetes mellitus (fasting blood glucose of >120 mg/dl or prior therapy), obesity (BMI >25), positive family history for CHD and smoking (current smokers) were obtained by viewing records and interviewing patients.

Gene_expression (levels) of HDL-cholesterol in blood associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension and disorder of lipid metabolism

16) Confidence 0.11 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2267783 Disease Relevance 2.01 Pain Relevance 0.14

In rats poisoned with small doses of lead, decreases in the plasma cholesterol level and the HDL-cholesterol fraction were observed.

Gene_expression (fraction) of HDL-cholesterol in plasma associated with disorder of lipid metabolism

17) Confidence 0.08 Published 1993 Journal Arch. Toxicol. Section Abstract Doc Link 8494500 Disease Relevance 0.64 Pain Relevance 0.07

Analytical procedures for the determination of glucose, LDL-cholesterol, HDL-cholesterol and triglycerides, thiobarbituric acid reactive substance concentrations (TBARs) and erythrocyte GPx activity (only measured at EVA2) have been described elsewhere [13].

Gene_expression (activity) of HDL-cholesterol in erythrocyte associated with disorder of lipid metabolism

18) Confidence 0.06 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2850339 Disease Relevance 0.93 Pain Relevance 0.12

In conclusion, policosanol administered at 10 mg/day produces more advantageous changes in HDL-cholesterol and has a better safety and tolerability profile than lovastatin 20 mg/day.

Gene_expression (produces) of HDL-cholesterol associated with disorder of lipid metabolism

19) Confidence 0.06 Published 1999 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 10939029 Disease Relevance 0.87 Pain Relevance 0

Whole serum proteins, albumin, C-reactive protein, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triacylglyceroles (triglycerides), apolipoprotein-B and electrophoretic levels of alpha-lipoprotein, beta-lipoprotein and pre-beta-lipoprotein were analysed immediately after the first clinical inspection in the hospital and then 30 days after treatment.

Gene_expression (levels) of HDL-cholesterol

20) Confidence 0.06 Published 2004 Journal Neuro Endocrinol. Lett. Section Body Doc Link 15159685 Disease Relevance 0.08 Pain Relevance 0

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